Literature DB >> 15330611

Concise synthesis of isoquinoline via the Ugi and Heck reactions.

Zheng Xiang1, Tuoping Luo, Kui Lu, Jiayue Cui, Xiaomeng Shi, Reza Fathi, Jiahua Chen, Zhen Yang.   

Abstract

[reaction: see text] Two types of isoquinoline scaffolds were successfully constructed in a combinatorial format via the Ugi four-component reaction and the Pd-catalyzed intramolecular Heck reaction, starting from readily available starting materials.

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Year:  2004        PMID： 15330611     DOI： 10.1021/ol048791n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

Review 1.  On the industrial applications of MCRs: molecular diversity in drug discovery and generic drug synthesis.

Authors:  Cédric Kalinski; Michael Umkehrer; Lutz Weber; Jürgen Kolb; Christoph Burdack; Günther Ross
Journal:  Mol Divers       Date:  2010-03-16       Impact factor: 2.943

2.  Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.

Authors:  Timothy J Donohoe; Ben S Pilgrim; Geraint R Jones; José A Bassuto
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-02       Impact factor: 11.205

3.  Short and efficient syntheses of protoberberine alkaloids using palladium-catalyzed enolate arylation.

Authors:  Alice E Gatland; Ben S Pilgrim; Panayiotis A Procopiou; Timothy J Donohoe
Journal:  Angew Chem Int Ed Engl       Date:  2014-10-27       Impact factor: 15.336

4.  Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization.

Authors:  Ben S Pilgrim; Alice E Gatland; Charlie T McTernan; Panayiotis A Procopiou; Timothy J Donohoe
Journal:  Org Lett       Date:  2013-11-19       Impact factor: 6.005

5.  Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions.

Authors:  Yuanze Wang; Pravin Patil; Katarzyna Kurpiewska; Justyna Kalinowska-Tluscik; Alexander Dömling
Journal:  Org Lett       Date:  2019-04-29       Impact factor: 6.005

6.  Xanthate based radical cascade toward multicomponent formation of pyrrolopyrimidines.

Authors:  Laurent El Kaïm; Laurence Grimaud; Patil Pravin
Journal:  Molecules       Date:  2011       Impact factor: 4.411

7.  Isoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction.

Authors:  Qian Wang; Kumchok C Mgimpatsang; Xin Li; Alexander Dömling
Journal:  J Org Chem       Date:  2021-06-29       Impact factor: 4.354
  7 in total

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