| Literature DB >> 1533042 |
Y Kasai1, J R Nambu, P M Lieberman, S T Crews.
Abstract
The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.Entities:
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Year: 1992 PMID： 1533042 PMCID： PMC48878 DOI： 10.1073/pnas.89.8.3414
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205