BACKGROUND: Mediterranean and high carbohydrate diets play a dominant role in the prevention of atherosclerosis as a result of their lipid lowering effect. However, diets can also have a protective effect in other ways, such as modulating tissue factor expression in circulating monocytes. METHODS AND RESULTS:Forty-one subjects participated in this randomised crossover study consisting of three dietary periods: a saturated fat enriched diet (SFA), a low fat and high carbohydrate diet (CHO), and a Mediterranean diet. Plasma levels of total cholesterol, triglycerides, low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) were determined at the end of each dietary period, as was the expression of tissue factor (TF) in circulating monocytes isolated from blood samples. Total cholesterol, LDL-C, HDL-C and TF expression were lower after the Mediterranean and high carbohydrate diets than after the SFA diet, and there was a positive correlation between LDL-C levels and monocyte TF expression. CONCLUSIONS:High carbohydrate and Mediterranean diets reduce the expression of TF in circulating monocytes.
RCT Entities:
BACKGROUND: Mediterranean and high carbohydrate diets play a dominant role in the prevention of atherosclerosis as a result of their lipid lowering effect. However, diets can also have a protective effect in other ways, such as modulating tissue factor expression in circulating monocytes. METHODS AND RESULTS: Forty-one subjects participated in this randomised crossover study consisting of three dietary periods: a saturated fat enriched diet (SFA), a low fat and high carbohydrate diet (CHO), and a Mediterranean diet. Plasma levels of total cholesterol, triglycerides, low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) were determined at the end of each dietary period, as was the expression of tissue factor (TF) in circulating monocytes isolated from blood samples. Total cholesterol, LDL-C, HDL-C and TF expression were lower after the Mediterranean and high carbohydrate diets than after the SFA diet, and there was a positive correlation between LDL-C levels and monocyte TF expression. CONCLUSIONS: High carbohydrate and Mediterranean diets reduce the expression of TF in circulating monocytes.
Authors: Aurelio Seidita; Maurizio Soresi; Lydia Giannitrapani; Vita Di Stefano; Roberto Citarrella; Luigi Mirarchi; Antonella Cusimano; Giuseppa Augello; Antonio Carroccio; Juan Lucio Iovanna; Melchiorre Cervello Journal: Front Nutr Date: 2022-08-04
Authors: Elena M Yubero-Serrano; Javier Lopez-Moreno; Francisco Gomez-Delgado; Jose Lopez-Miranda Journal: Eur J Clin Nutr Date: 2019-07 Impact factor: 4.016
Authors: Paola Ditano-Vázquez; José David Torres-Peña; Francisco Galeano-Valle; Ana Isabel Pérez-Caballero; Pablo Demelo-Rodríguez; José Lopez-Miranda; Niki Katsiki; Javier Delgado-Lista; Luis A Alvarez-Sala-Walther Journal: Nutrients Date: 2019-11-19 Impact factor: 5.717