BACKGROUND: Cyclooxygenase-2 (COX-2) overexpression clearly plays an important role in the pathogenesis of breast cancer. In this study, we analysed the relationship between COX-2 expression and various clinicopathological factors in human breast cancer. MATERIALS AND METHODS: Using immunohistochemistry, we analysed archival specimens of human breast cancer (n=29) using antibodies to COX-2, ER, PgR and HER2 and, from medical records, obtained clinicopathological data. RESULTS: We observed a significant association between COX-2 overexpression and distant metastasis. COX-2 expression was not significantly associated with any other clinical or pathological variable. CONCLUSION: These findings lend support to the hypothesis that COX-2 overexpression represents an adverse prognostic event in human breast cancer and are encouraging for proposed strategies of COX-2 suppression to treat the disease.
BACKGROUND:Cyclooxygenase-2 (COX-2) overexpression clearly plays an important role in the pathogenesis of breast cancer. In this study, we analysed the relationship between COX-2 expression and various clinicopathological factors in humanbreast cancer. MATERIALS AND METHODS: Using immunohistochemistry, we analysed archival specimens of humanbreast cancer (n=29) using antibodies to COX-2, ER, PgR and HER2 and, from medical records, obtained clinicopathological data. RESULTS: We observed a significant association between COX-2 overexpression and distant metastasis. COX-2 expression was not significantly associated with any other clinical or pathological variable. CONCLUSION: These findings lend support to the hypothesis that COX-2 overexpression represents an adverse prognostic event in humanbreast cancer and are encouraging for proposed strategies of COX-2 suppression to treat the disease.
Authors: Michelle D Holmes; Wendy Y Chen; Lisa Li; Ellen Hertzmark; Donna Spiegelman; Susan E Hankinson Journal: J Clin Oncol Date: 2010-02-16 Impact factor: 44.544
Authors: Isabella W Cheuk; Vivian Y Shin; Man T Siu; Julia Y Tsang; John C Ho; Jiawei Chen; Gary M Tse; Xian Wang; Ava Kwong Journal: Am J Cancer Res Date: 2015-10-15 Impact factor: 6.166
Authors: Holger Bronger; Sara Kraeft; Ulrike Schwarz-Boeger; Claudia Cerny; Alexandra Stöckel; Stefanie Avril; Marion Kiechle; Manfred Schmitt Journal: Breast Cancer Res Date: 2012-02-14 Impact factor: 6.466