Literature DB >> 15328106

Effect of ertapenem protein binding on killing of bacteria.

David E Nix1, Kathryn R Matthias, Emily C Ferguson.   

Abstract

The effect of protein binding on the antimicrobial activity of ertapenem was evaluated using the bacterial kill rate and concentration-response studies. Various proportions of human serum were utilized to determine the total and free-drug concentrations using a validated high-performance liquid chromatography assay. The MICs and kill curves were determined for test isolates of Enterobacter cloacae and Staphylococcus aureus at various percentages of human serum. The killing of bacteria was analyzed in relation to the free and total concentrations of ertapenem at various proportions of human serum. It was determined that unbound ertapenem was responsible for the antimicrobial activity against the test isolates.

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Year:  2004        PMID： 15328106      PMCID： PMC514739          DOI： 10.1128/AAC.48.9.3419-3424.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Authors:  L R Peterson; W H Hall; H H Zinneman; D N Gerding
Journal:  J Infect Dis       Date:  1977-12       Impact factor: 5.226

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Authors:  G Drusano; H Standiford; P Ryan; W McNamee; B Tatem; S Schimpff
Journal:  Eur J Clin Microbiol       Date:  1986-02       Impact factor: 3.267

3.  Antimicrobial activity of ceftriaxone, cefotaxime, desacetylcefotaxime, and cefotaxime-desacetylcefotaxime in the presence of human serum.

Authors:  R N Jones; A L Barry
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191

4.  Clinical pharmacology of the new penicillins. 1. The importance of serum protein binding in determining antimicrobial activity and concentration in serum.

Authors:  C M Kunin
Journal:  Clin Pharmacol Ther       Date:  1966 Mar-Apr       Impact factor: 6.875

5.  Serum dilution test for bactericidal activity. II. Standardization and correlation with antimicrobial assays and susceptibility tests.

Authors:  L B Reller; C W Stratton
Journal:  J Infect Dis       Date:  1977-08       Impact factor: 5.226

6.  Anomalous effect of serum on the antimicrobial activity of cefoperazone.

Authors:  S D Lang; G L Cameron; P R Mullins
Journal:  Drugs       Date:  1981       Impact factor: 9.546

7.  Effect of protein binding on antibiotic activity in vivo.

Authors:  D J Merrikin; J Briant; G N Rolinson
Journal:  J Antimicrob Chemother       Date:  1983-03       Impact factor: 5.790

8.  Effect of antibiotic protein binding on the killing rate of Staphylococcus aureus and on the paradoxical phenomenon.

Authors:  I Odenholt; S E Holm; O Cars
Journal:  Chemotherapy       Date:  1987       Impact factor: 2.544

Review 9.  Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid.

Authors:  William A Craig
Journal:  Infect Dis Clin North Am       Date:  2003-09       Impact factor: 5.982

10.  Enhancing effect of serum ultrafiltrate on the activity of cephalosporins against gram-negative bacilli.

Authors:  J E Leggett; W A Craig
Journal:  Antimicrob Agents Chemother       Date:  1989-01       Impact factor: 5.191
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  13 in total

Review 1.  Protein binding of antimicrobials: methods for quantification and for investigation of its impact on bacterial killing.

Authors:  Jürgen Beer; Claudia Christina Wagner; Markus Zeitlinger
Journal:  AAPS J       Date:  2009-01-01       Impact factor: 4.009

2.  Effect of protein binding on the pharmacological activity of highly bound antibiotics.

Authors:  Stephan Schmidt; Katharina Röck; Martina Sahre; Olaf Burkhardt; Martin Brunner; Maximilian T Lobmeyer; Hartmut Derendorf
Journal:  Antimicrob Agents Chemother       Date:  2008-09-08       Impact factor: 5.191

Review 3.  Protein binding: do we ever learn?

Authors:  Markus A Zeitlinger; Hartmut Derendorf; Johan W Mouton; Otto Cars; William A Craig; David Andes; Ursula Theuretzbacher
Journal:  Antimicrob Agents Chemother       Date:  2011-05-02       Impact factor: 5.191

4.  Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients.

Authors:  Yasuhiro Tsuji; Nicholas H G Holford; Hidefumi Kasai; Chika Ogami; Young-A Heo; Yoshitsugu Higashi; Akiko Mizoguchi; Hideto To; Yoshihiro Yamamoto
Journal:  Br J Clin Pharmacol       Date:  2017-03-31       Impact factor: 4.335

Review 5.  Ertapenem: a review of its use in the treatment of bacterial infections.

Authors:  Gillian M Keating; Caroline M Perry
Journal:  Drugs       Date:  2005       Impact factor: 9.546

6.  Pharmacokinetics of ertapenem in critically ill patients receiving continuous venovenous hemodialysis or hemodiafiltration.

Authors:  Rachel F Eyler; A Mary Vilay; Ahmed M Nader; Michael Heung; Melissa Pleva; Kevin M Sowinski; Daryl D DePestel; Fritz Sörgel; Martina Kinzig; Bruce A Mueller
Journal:  Antimicrob Agents Chemother       Date:  2013-12-09       Impact factor: 5.191

7.  Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.

Authors:  April Barbour; Stephan Schmidt; Sreedharan Nair Sabarinath; Maria Grant; Christoph Seubert; Donna Skee; Bindu Murthy; Hartmut Derendorf
Journal:  Antimicrob Agents Chemother       Date:  2009-04-13       Impact factor: 5.191

8.  Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.

Authors:  Mohammad A K Azad; Johnny X Huang; Matthew A Cooper; Kade D Roberts; Philip E Thompson; Roger L Nation; Jian Li; Tony Velkov
Journal:  Biochem Pharmacol       Date:  2012-05-12       Impact factor: 5.858

9.  Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations.

Authors:  Johnny X Huang; Matthew A Cooper; Mark A Baker; Mohammad A K Azad; Roger L Nation; Jian Li; Tony Velkov
Journal:  J Mol Recognit       Date:  2012-12       Impact factor: 2.137

Review 10.  Antimicrobial Activity and Resistance: Influencing Factors.

Authors:  Jun Li; Shuyu Xie; Saeed Ahmed; Funan Wang; Yufeng Gu; Chaonan Zhang; Ximan Chai; Yalan Wu; Jinxia Cai; Guyue Cheng
Journal:  Front Pharmacol       Date:  2017-06-13       Impact factor: 5.810
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