| Literature DB >> 15327310 |
Xi Zhang1, Huaping Xu, Zeyuan Dong, Yapei Wang, Junqiu Liu, Jiacong Shen.
Abstract
In this communication, we report the synthesis of the three generations of Fréchet-type poly(aryl ether) dendrimers with a diselenide core that demonstrate generation-dependent glutathione peroxidase (GPx) activity with initial reduction rates as high as 2431.20 muM min-1 for the third-generation product, around 1400 times faster than Ebselen. It represents a successful example of using a dendrimer as a model for a GPx mimic.Entities:
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Year: 2004 PMID： 15327310 DOI： 10.1021/ja048890w
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419