Literature DB >> 1532588

Conserved mechanism of negative gene regulation by extracellular calcium. Parathyroid hormone gene versus atrial natriuretic polypeptide gene.

T Okazaki1, K Ando, T Igarashi, E Ogata, T Fujita.   

Abstract

We found that a negative calcium-responsive element (nCaRE) originally reported in the human parathyroid hormone gene is conserved among several genes. The results of the present study show that expression of one of the genes, the rat atrial natriuretic polypeptide gene, was negatively regulated in the heart by extracellular calcium by using an in vivo infusion system. Moreover, transfection of the cultured cells revealed that this DNA element conferred negative regulation by extracellular calcium on the reporter gene. It is suggested that there is a gene family whose expression is negatively regulated by extracellular calcium through this conserved DNA motif, nCaRE.

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Year:  1992        PMID： 1532588      PMCID： PMC442987          DOI： 10.1172/JCI115711

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  24 in total

Review 1.  RNA polymerase B (II) and general transcription factors.

Authors:  M Sawadogo; A Sentenac
Journal:  Annu Rev Biochem       Date:  1990       Impact factor: 23.643

2.  5'-flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3.

Authors:  T Okazaki; T Igarashi; H M Kronenberg
Journal:  J Biol Chem       Date:  1988-02-15       Impact factor: 5.157

3.  Salt sensitivity in hypertensive rats with angiotensin II administration.

Authors:  K Ando; Y Sato; T Fujita
Journal:  Am J Physiol       Date:  1990-11

4.  DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.

Authors:  M B Demay; J M Gerardi; H F DeLuca; H M Kronenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

5.  Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

Authors:  H F Yang-Yen; J C Chambard; Y L Sun; T Smeal; T J Schmidt; J Drouin; M Karin
Journal:  Cell       Date:  1990-09-21       Impact factor: 41.582

6.  Negative regulatory elements in the human parathyroid hormone gene.

Authors:  T Okazaki; J D Zajac; T Igarashi; E Ogata; H M Kronenberg
Journal:  J Biol Chem       Date:  1991-11-15       Impact factor: 5.157

7.  Hypocalcemia increases and hypercalcemia decreases the steady-state level of parathyroid hormone messenger RNA in the rat.

Authors:  M Yamamoto; T Igarashi; M Muramatsu; M Fukagawa; T Motokura; E Ogata
Journal:  J Clin Invest       Date:  1989-03       Impact factor: 14.808

8.  Effect of external Ca2+ concentration on stretch-augmented natriuretic peptide secretion by rat atria.

Authors:  E Page; J Upshaw-Earley; G E Goings; D A Hanck
Journal:  Am J Physiol       Date:  1991-04

9.  Effect of manipulations of Ca2+ environment on atrial natriuretic factor release.

Authors:  M L De Bold; A J De Bold
Journal:  Am J Physiol       Date:  1989-06

10.  Stretch-induced atriopeptin secretion in the isolated rat myocyte and its negative modulation by calcium.

Authors:  J E Greenwald; M Apkon; K A Hruska; P Needleman
Journal:  J Clin Invest       Date:  1989-03       Impact factor: 14.808
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  6 in total

1.  Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.

Authors:  David T Kuninger; Tadahide Izumi; John Papaconstantinou; Sankar Mitra
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

Review 2.  Negative regulation of transcription in eukaryotes.

Authors:  A R Clark; K Docherty
Journal:  Biochem J       Date:  1993-12-15       Impact factor: 3.857

3.  Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

Authors:  Kishor K Bhakat; Tadahide Izumi; Suk-Hoon Yang; Tapas K Hazra; Sankar Mitra
Journal:  EMBO J       Date:  2003-12-01       Impact factor: 11.598

4.  SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.

Authors:  Giulia Antoniali; Lisa Lirussi; Chiara D'Ambrosio; Fabrizio Dal Piaz; Carlo Vascotto; Elena Casarano; Daniela Marasco; Andrea Scaloni; Federico Fogolari; Gianluca Tell
Journal:  Mol Biol Cell       Date:  2013-12-19       Impact factor: 4.138

Review 5.  Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair.

Authors:  Hiroyuki Matsuda; Pavel Hamet; Johanne Tremblay
Journal:  J Nephrol       Date:  2014-02-11       Impact factor: 3.902

6.  An Excess of CYP24A1, Lack of CaSR, and a Novel lncRNA Near the PTH Gene Characterize an Ectopic PTH-Producing Tumor.

Authors:  Kosuke Uchida; Yuji Tanaka; Hitoshi Ichikawa; Masato Watanabe; Sachiyo Mitani; Koji Morita; Hiroko Fujii; Mayumi Ishikawa; Gen Yoshino; Hiroko Okinaga; Genta Nagae; Hiroyuki Aburatani; Yoshifumi Ikeda; Takao Susa; Mimi Tamamori-Adachi; Toshio Fukusato; Hiroshi Uozaki; Tomoki Okazaki; Masayoshi Iizuka
Journal:  J Endocr Soc       Date:  2017-05-03
  6 in total

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