| Literature DB >> 15325206 |
Eduardo Alves de Almeida1, Sayuri Miyamoto, Afonso Celso Dias Bainy, Marisa Helena Gennari de Medeiros, Paolo Di Mascio.
Abstract
Levels of antioxidant defenses and lipid peroxidation were evaluated in mussels exposed to lead (200 mg/l), iron (500 microg/l), cadmium (200 microg/l) and copper (40 microg/l), for 12, 24, 72 and 120 h. Glutathione S-transferase (GST) activity was unchanged with all treatments. Catalase (CAT) increased after 120 h of exposure to all metals. Mussels exposed to Cd for 12 h, and to Cu and Fe for 120 h had increased lipid peroxidation, which might be associated to decreased levels of reduced glutathione (GSH) and glutathione peroxidase (GPx) activity. Pb exposure caused GSH depletion after 12 h and increased GPx activity after 120 h. Negative correlations were observed between the enzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) and malonaldehyde (MDA) levels after Fe and Cu exposure, indicating a protective role of PHGPx against lipid peroxidation, and suggesting the use of this enzyme as a new potential biomarker of toxicity associated with contaminant exposure in mussels. Copyright 2004 Elsevier Ltd.Entities:
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Year: 2004 PMID： 15325206 DOI： 10.1016/j.marpolbul.2004.02.020
Source DB: PubMed Journal: Mar Pollut Bull ISSN： 0025-326X Impact factor: 5.553