Literature DB >> 15324909

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.

Ahmed Kamal1, P Ramulu, O Srinivas, G Ramesh, P Praveen Kumar.   

Abstract

Two types of benzimidazoles have been synthesized and linked to DC-81 at C8-position through different alkyl chain spacers. These PBD conjugates have exhibited remarkable DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

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Year:  2004        PMID： 15324909     DOI： 10.1016/j.bmcl.2004.06.069

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Fluorogenic label for biomolecular imaging.

Authors:  Luke D Lavis; Tzu-Yuan Chao; Ronald T Raines
Journal:  ACS Chem Biol       Date:  2006-05-23       Impact factor: 5.100

2.  Synthesis and investigation of novel benzimidazole derivatives as antifungal agents.

Authors:  Nishad Thamban Chandrika; Sanjib K Shrestha; Huy X Ngo; Sylvie Garneau-Tsodikova
Journal:  Bioorg Med Chem       Date:  2016-06-04       Impact factor: 3.641

3.  Functionalization of carboxylated multiwall nanotubes with imidazole derivatives and their toxicity investigations.

Authors:  Javad Azizian; Hasan Tahermansouri; Esmaeil Biazar; Saeed Heidari; Davood Chobfrosh Khoei
Journal:  Int J Nanomedicine       Date:  2010-11-04
  3 in total

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