| Literature DB >> 15324898 |
Lawrence B Snyder1, Zhaoxing Meng, Robert Mate, Stanley V D'Andrea, Anne Marinier, Claude A Quesnelle, Patrice Gill, Kenneth L DenBleyker, Joan C Fung-Tomc, MaryBeth Frosco, Alain Martel, John F Barrett, Joanne J Bronson.
Abstract
A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared. The design concept involved replacement of the requisite sp(3)-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, pyrroles, and isoxazolinones is described.Entities:
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Year: 2004 PMID： 15324898 DOI： 10.1016/j.bmcl.2004.06.076
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823