| Literature DB >> 15324893 |
Srinivas Nanduri1, Vijay Kumar Nyavanandi, Siva Sanjeeva Rao Thunuguntla, Sridevi Kasu, Mahesh Kumar Pallerla, P Sai Ram, Sriram Rajagopal, R Ajaya Kumar, Rajagopalan Ramanujam, J Moses Babu, Krishnamurthi Vyas, A Sivalakshmi Devi, G Om Reddy, Venkateswarlu Akella.
Abstract
Andrographolide 1, the cytotoxic agent of the plant Andrographis paniculata was subjected to semi-synthetic studies leading to the preparation of a number of potent and novel analogues. Of the analogues synthesized, while 8,17-epoxy andrographolide 6 retained the cytotoxic activity of 1, ester derivatives of 6 exhibited considerable improvement in activity. Lower activity was observed when the epoxy moiety in the triacetate 9, derived from 6 was modified. Synthesis and structure-activity relationships are discussed.Entities:
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Year: 2004 PMID： 15324893 DOI： 10.1016/j.bmcl.2004.06.090
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823