| Literature DB >> 15324876 |
Edwige Lorthiois1, Patrick Bernardelli, Fabrice Vergne, Chrystelle Oliveira, Abdel-Kader Mafroud, Emmanuelle Proust, Lamia Heuze, François Moreau, Moulay Idrissi, Anita Tertre, Bernadette Bertin, Magali Coupe, Roger Wrigglesworth, Arnaud Descours, Patricia Soulard, Patrick Berna.
Abstract
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.Entities:
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Year: 2004 PMID： 15324876 DOI： 10.1016/j.bmcl.2004.07.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823