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Literature DB >> 1532399

Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis.

P De Paoli¹, G Basaglia, D Gennari, M Crovatto, M L Modolo, G Santini.

Abstract

Gamma and delta (gamma delta) T-cell receptor lymphocytes are increased during acute toxoplasmosis. These cells are BB3+ CD45RO+ CD8-. Purified gamma delta T cells failed to proliferate in response to Toxoplasma gondii antigen (stimulation index, 1.4 +/- 0.6) but were responsive to phytohemagglutinin stimulation (stimulation index, 20.8 +/- 1.9). Natural-killer-like cytotoxicity was strongly acquired only after in vitro culture of purified gamma delta T cells with recombinant interleukin 2 (40% +/- 7% specific lysis). Our data show that gamma delta T-cell receptor T cells with a peculiar phenotype are increased during human acute T. gondii infection.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1532399 PMCID： PMC265143 DOI： 10.1128/jcm.30.3.729-731.1992

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

17 in total

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6. Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta+ lymphocytes.

Authors: T Miyawaki; Y Kasahara; K Taga; A Yachie; N Taniguchi
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Authors: S D Sharma; J M Hofflin; J S Remington
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Authors: P De Paoli; D Gennari; P Martelli; V Cavarzerani; R Comoretto; G Santini
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Authors: E M Janis; S H Kaufmann; R H Schwartz; D M Pardoll
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15 in total

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Journal: Br J Ophthalmol Date: 2005-12 Impact factor: 4.638

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Authors: K Himeno; H Hisaeda
Journal: Immunol Res Date: 1996 Impact factor: 2.829

4. Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii.

Authors: H Hisaeda; T Sakai; H Nagasawa; H Ishikawa; K Yasutomo; Y Maekawa; K Himeno
Journal: Immunology Date: 1996-08 Impact factor: 7.397

5. Preferential activation and expansion of human peripheral blood gamma delta T cells in response to Toxoplasma gondii in vitro and their cytokine production and cytotoxic activity against T. gondii-infected cells.

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Authors: C Behr; R Poupot; M A Peyrat; Y Poquet; P Constant; P Dubois; M Bonneville; J J Fournie
Journal: Infect Immun Date: 1996-08 Impact factor: 3.441

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Authors: L E Leiva; J Junprasert; D Hollenbaugh; R U Sorensen
Journal: J Clin Immunol Date: 1998-07 Impact factor: 8.317