Literature DB >> 15323585

Mechanism of action of alpha2delta ligands: voltage sensitive calcium channel (VSCC) modulators.

Stephen M Stahl1.   

Abstract

ISSUE: Voltage sensitive calcium channels (VSCCs) have unique structures and functions that distinguish them from other ion channels, especially the voltage sensitive sodium channels (VSSCs). Modulation of VSCCs by certain drugs such as pregabalin and gabapentin via binding to the alpha2delta subunits of VSCCs can lead to anticonvulsant, anxiolytic, and chronic pain-relieving actions.

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Year:  2004        PMID： 15323585     DOI： 10.4088/jcp.v65n0801

Source DB:  PubMed          Journal:  J Clin Psychiatry        ISSN： 0160-6689            Impact factor:   4.384


  14 in total

1.  Pregabalin- and topiramate-mediated regulation of cognitive and motor impulsivity in DBA/2 mice.

Authors:  Francisco Navarrete; José M Pérez-Ortiz; Jorge Manzanares
Journal:  Br J Pharmacol       Date:  2012-09       Impact factor: 8.739

Review 2.  Enriched enrollment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review.

Authors:  Sebastian Straube; Sheena Derry; Henry J McQuay; R Andrew Moore
Journal:  Br J Clin Pharmacol       Date:  2008-04-11       Impact factor: 4.335

Review 3.  Oral pregabalin for acute pain relief after cervicofacial surgery: a systematic review.

Authors:  Sara Liébana-Hermoso; Francisco Javier Manzano-Moreno; Manuel Francisco Vallecillo-Capilla; Maria Victoria Olmedo-Gaya
Journal:  Clin Oral Investig       Date:  2017-11-03       Impact factor: 3.573

4.  Comparing Gabapentin with Clonazepam for Residual Sleeping Problems following Antidepressant Therapy in Patients with Major Depressive Disorder: A Randomized Clinical Trial.

Authors:  Arash Mowla; Laaya Ahmadzadeh; Leila Razeghian Jahromi; Seyed Ali Dastgheib
Journal:  Clin Drug Investig       Date:  2015-08       Impact factor: 2.859

5.  Antiallodynic effect of pregabalin in rat models of sympathetically maintained and sympathetic independent neuropathic pain.

Authors:  Dong Woo Han; Tae Dong Kweon; Jong Seok Lee; Youn-Woo Lee
Journal:  Yonsei Med J       Date:  2007-02-28       Impact factor: 2.759

Review 6.  Pregabalin in the treatment of alcohol and benzodiazepines dependence.

Authors:  Panagiotis Oulis; George Konstantakopoulos
Journal:  CNS Neurosci Ther       Date:  2010       Impact factor: 5.243

7.  Current diagnosis and treatment of anxiety disorders.

Authors:  Alexander Bystritsky; Sahib S Khalsa; Michael E Cameron; Jason Schiffman
Journal:  P T       Date:  2013-01

8.  A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia.

Authors:  Kirk J Brower; Hyungjin Myra Kim; Stephen Strobbe; Maher A Karam-Hage; Flavia Consens; Robert A Zucker
Journal:  Alcohol Clin Exp Res       Date:  2008-06-06       Impact factor: 3.455

Review 9.  Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2).

Authors:  Amos D Korczyn; Steven C Schachter; Martin J Brodie; Sarang S Dalal; Jerome Engel; Alla Guekht; Hrvoje Hecimovic; Karim Jerbi; Andres M Kanner; Cecilie Johannessen Landmark; Pavel Mares; Petr Marusic; Stefano Meletti; Marco Mula; Philip N Patsalos; Markus Reuber; Philippe Ryvlin; Klára Štillová; Roberto Tuchman; Ivan Rektor
Journal:  Epilepsy Behav       Date:  2013-06-10       Impact factor: 2.937

10.  Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine.

Authors:  J M P Baas; N Mol; J L Kenemans; E P Prinssen; I Niklson; C Xia-Chen; F Broeyer; J van Gerven
Journal:  Psychopharmacology (Berl)       Date:  2009-05-05       Impact factor: 4.530
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