| Literature DB >> 1532322 |
E Meyer1, W Lambert, A De Leenheer, J De Bersaques, A Kint.
Abstract
The concentrations of trans-acitretin and its principal metabolite, cis-acitretin, were measured by h.p.l.c. after single and multiple dosing (50 mg orally for 13 days) in plasma, blister fluid and epidermal samples from four healthy male volunteers. Within-day epidermal concentrations of trans-acitretin exceeded those of the cis-form which were at the limit of assay sensitivity. No accumulation of trans-acitretin was observed in plasma or blister fluid but AUC values for the drug in blister roof cells tended to be higher after multiple dosing.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1532322 PMCID： PMC1381306 DOI： 10.1111/j.1365-2125.1992.tb04023.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335