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Literature DB >> 15322058

The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model.

Michelle L Zaharik¹, Vivian Li Cullen, Angela M Fung, Stephen J Libby, Sonya L Kujat Choy, Bryan Coburn, David G Kehres, Michael E Maguire, Ferric C Fang, B Brett Finlay.

Abstract

Nramp1 is a transporter that pumps divalent cations from the vacuoles of phagocytic cells and is associated with the innate resistance of mice to diverse intracellular pathogens. We demonstrate that sitA and mntH, genes encoding high-affinity metal ion uptake systems in Salmonella enterica serovar Typhimurium, are upregulated when Salmonella is internalized by Nramp1-expressing macrophages and play an essential role in systemic infection of congenic Nramp1-expressing mice.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15322058 PMCID： PMC517450 DOI： 10.1128/IAI.72.9.5522-5525.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

25 in total

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63 in total

Review 1. The role of ATP-binding cassette transporters in bacterial pathogenicity.

Authors: Victoria G Lewis; Miranda P Ween; Christopher A McDevitt
Journal: Protoplasma Date: 2012-01-13 Impact factor: 3.356

2. Microarray-based detection of Salmonella enterica serovar Typhimurium transposon mutants that cannot survive in macrophages and mice.

Authors: Kaman Chan; Charles C Kim; Stanley Falkow
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

Review 3. Host-imposed manganese starvation of invading pathogens: two routes to the same destination.

Authors: Jacqueline R Morey; Christopher A McDevitt; Thomas E Kehl-Fie
Journal: Biometals Date: 2015-04-03 Impact factor: 2.949

4. Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice.

Authors: Ferric C Fang; Stephen J Libby; Margaret E Castor; Angela M Fung
Journal: Infect Immun Date: 2005-04 Impact factor: 3.441

5. Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp.

Authors: Nadia Benaroudj; Frederick Saul; Jacques Bellalou; Isabelle Miras; Patrick Weber; Vincent Bondet; Gerald L Murray; Ben Adler; Paula Ristow; Hélène Louvel; Ahmed Haouz; Mathieu Picardeau
Journal: J Bacteriol Date: 2013-10-11 Impact factor: 3.490

6. Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis.

Authors: Binh An Diep; Qui Phung; Shailesh Date; David Arnott; Corey Bakalarski; Min Xu; Gerald Nakamura; Danielle L Swem; Mary Kate Alexander; Hoan N Le; Thuy T Mai; Man-Wah Tan; Eric J Brown; Mireille Nishiyama
Journal: J Infect Dis Date: 2013-11-26 Impact factor: 5.226