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Literature DB >> 15322057

The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites.

K Rajeshwari¹, Kalpesh Patel, Savithri Nambeesan, Monika Mehta, Alfica Sehgal, Tirtha Chakraborty, Shobhona Sharma.

Abstract

Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.

Entities: Disease Species

Mesh：

Substances：

Year: 2004 PMID： 15322057 PMCID： PMC517436 DOI： 10.1128/IAI.72.9.5515-5521.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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