Literature DB >> 15322051

Both expansion of regulatory GR1+ CD11b+ myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis.

Mathieu-Benoît Voisin1, Dominique Buzoni-Gatel, Daniel Bout, Florence Velge-Roussel.   

Abstract

Oral infection with Toxoplasma gondii leads to transient systemic hyporesponsiveness. In this report, we characterized the presence in the lungs of GR1(+) CD11b(+) myeloid cells that have potent nitric oxide-dependent immunoregulatory properties. We also demonstrated the interleukin 2-reversible anergy of both pulmonary CD8(+) and CD4(+) activated T lymphocytes with infection.

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Year:  2004        PMID: 15322051      PMCID: PMC517443          DOI: 10.1128/IAI.72.9.5487-5492.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  32 in total

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  38 in total

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8.  Myeloid-derived suppressor cells in murine retrovirus-induced AIDS inhibit T- and B-cell responses in vitro that are used to define the immunodeficiency.

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