Literature DB >> 15322047

Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine.

Yangming Xiao1, Youmin Zhong, Whitney Greene, Feng Dong, Guangming Zhong.   

Abstract

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

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Year:  2004        PMID： 15322047      PMCID： PMC517444          DOI： 10.1128/IAI.72.9.5470-5474.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Conformation of the Bax C-terminus regulates subcellular location and cell death.

Authors:  A Nechushtan; C L Smith; Y T Hsu; R J Youle
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

2.  Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death.

Authors:  M C Wei; W X Zong; E H Cheng; T Lindsten; V Panoutsakopoulou; A J Ross; K A Roth; G R MacGregor; C B Thompson; S J Korsmeyer
Journal:  Science       Date:  2001-04-27       Impact factor: 47.728

Review 3.  Host defense, viruses and apoptosis.

Authors:  G N Barber
Journal:  Cell Death Differ       Date:  2001-02       Impact factor: 15.828

4.  Bax directly induces release of cytochrome c from isolated mitochondria.

Authors:  J M Jürgensmeier; Z Xie; Q Deveraux; L Ellerby; D Bredesen; J C Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

5.  Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis.

Authors:  Whitney Greene; Yangming Xiao; Yanqing Huang; Grant McClarty; Guangming Zhong
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

6.  Protection against CD95-induced apoptosis by chlamydial infection at a mitochondrial step.

Authors:  Silke F Fischer; Thomas Harlander; Juliane Vier; Georg Häcker
Journal:  Infect Immun       Date:  2004-02       Impact factor: 3.441

7.  Movement of Bax from the cytosol to mitochondria during apoptosis.

Authors:  K G Wolter; Y T Hsu; C L Smith; A Nechushtan; X G Xi; R J Youle
Journal:  J Cell Biol       Date:  1997-12-01       Impact factor: 10.539

8.  Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors.

Authors:  G Zhong; P Fan; H Ji; F Dong; Y Huang
Journal:  J Exp Med       Date:  2001-04-16       Impact factor: 14.307

9.  Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation.

Authors:  T Fan; H Lu; H Hu; L Shi; G A McClarty; D M Nance; A H Greenberg; G Zhong
Journal:  J Exp Med       Date:  1998-02-16       Impact factor: 14.307

10.  Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis.

Authors:  G J Griffiths; L Dubrez; C P Morgan; N A Jones; J Whitehouse; B M Corfe; C Dive; J A Hickman
Journal:  J Cell Biol       Date:  1999-03-08       Impact factor: 10.539
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  37 in total

1.  Localization and characterization of GTP-binding protein CT703 in the Chlamydia trachomatis-Infected cells.

Authors:  Kun Du; Fuyan Wang; Zhi Huo; Jie Wang; Wen Cheng; Ming Li; Ping Yu
Journal:  Curr Microbiol       Date:  2010-08-20       Impact factor: 2.188

2.  Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells.

Authors:  Feng Dong; Mustak Pirbhai; Yangming Xiao; Youmin Zhong; Yimou Wu; Guangming Zhong
Journal:  Infect Immun       Date:  2005-03       Impact factor: 3.441

Review 3.  Apoptosis in infectious disease: how bacteria interfere with the apoptotic apparatus.

Authors:  Georg Häcker; Susanne Kirschnek; Silke F Fischer
Journal:  Med Microbiol Immunol       Date:  2005-08-06       Impact factor: 3.402

4.  Localization of the hypothetical protein Cpn0797 in the cytoplasm of Chlamydia pneumoniae-infected host cells.

Authors:  Feng Dong; Rhonda Flores; Ding Chen; Jianhua Luo; Youmin Zhong; Zhongming Wu; Guangming Zhong
Journal:  Infect Immun       Date:  2006-11       Impact factor: 3.441

Review 5.  Apoptosis inhibition by intracellular bacteria and its consequence on host immunity.

Authors:  Samuel M Behar; Volker Briken
Journal:  Curr Opin Immunol       Date:  2019-06-19       Impact factor: 7.486

Review 6.  Staying alive: bacterial inhibition of apoptosis during infection.

Authors:  Christina S Faherty; Anthony T Maurelli
Journal:  Trends Microbiol       Date:  2008-03-18       Impact factor: 17.079

7.  Chlamydia trachomatis infection modulates trophoblast cytokine/chemokine production.

Authors:  Eugenia de la Torre; Melissa J Mulla; Andrew G Yu; Seung-Joon Lee; Paula B Kavathas; Vikki M Abrahams
Journal:  J Immunol       Date:  2009-03-15       Impact factor: 5.422

8.  The chlamydial plasmid-encoded protein pgp3 is secreted into the cytosol of Chlamydia-infected cells.

Authors:  Zhongyu Li; Ding Chen; Youmin Zhong; Shiping Wang; Guangming Zhong
Journal:  Infect Immun       Date:  2008-05-12       Impact factor: 3.441

9.  In vitro infection of bovine monocytes with Mycoplasma bovis delays apoptosis and suppresses production of gamma interferon and tumor necrosis factor alpha but not interleukin-10.

Authors:  Musa Mulongo; Tracy Prysliak; Erin Scruten; Scott Napper; Jose Perez-Casal
Journal:  Infect Immun       Date:  2013-10-14       Impact factor: 3.441

Review 10.  Killing me softly: chlamydial use of proteolysis for evading host defenses.

Authors:  Guangming Zhong
Journal:  Trends Microbiol       Date:  2009-09-16       Impact factor: 17.079
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