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Literature DB >> 15322046

Helicobacter pylori infection of human and murine primary gastric cells.

Abstract

The effect of Helicobacter pylori infection on human and murine primary gastric cells was determined. CagA was phosphorylated following adherence of H. pylori to primary human gastric cells. However, it did not adhere to human primary duodenal cells or murine gastric cells, and CagA could not be detected in cell lysates. Identification of an easily available animal model of infection in which the organism adheres to gastric mucosal cells would enhance studies of the virulence of H. pylori.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15322046 PMCID： PMC517422 DOI： 10.1128/IAI.72.9.5464-5469.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

34 in total

1. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.

Authors: S Odenbreit; J Püls; B Sedlmaier; E Gerland; W Fischer; R Haas
Journal: Science Date: 2000-02-25 Impact factor: 47.728

2. Comparative analysis of colonization of Helicobacter pylori and glycolipids receptor density in Mongolian gerbils and mice.

Authors: H Osawa; K Sugano; M Iwamori; M Kawakami; M Tada; M Nakao
Journal: Dig Dis Sci Date: 2001-01 Impact factor: 3.199

3. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation.

Authors: M Stein; R Rappuoli; A Covacci
Journal: Proc Natl Acad Sci U S A Date: 2000-02-01 Impact factor: 11.205

4. Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus.

Authors: S Backert; E Ziska; V Brinkmann; U Zimny-Arndt; A Fauconnier; P R Jungblut; M Naumann; T F Meyer
Journal: Cell Microbiol Date: 2000-04 Impact factor: 3.715

5. Role of Helicobacter pylori cag region genes in colonization and gastritis in two animal models.

Authors: K A Eaton; D Kersulyte; M Mefford; S J Danon; S Krakowka; D E Berg
Journal: Infect Immun Date: 2001-05 Impact factor: 3.441

6. Characteristics of Helicobacter pylori attachment to human primary antral epithelial cells.

Authors: U Heczko; V C Smith; R Mark Meloche; A M Buchan; B B Finlay
Journal: Microbes Infect Date: 2000-11 Impact factor: 2.700

7. Helicobacter pylori possesses two CheY response regulators and a histidine kinase sensor, CheA, which are essential for chemotaxis and colonization of the gastric mucosa.

Authors: S Foynes; N Dorrell; S J Ward; R A Stabler; A A McColm; A N Rycroft; B W Wren
Journal: Infect Immun Date: 2000-04 Impact factor: 3.441

Helicobacter pylori infection of human and murine primary gastric cells.

1. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion.

2. Comparative analysis of colonization of Helicobacter pylori and glycolipids receptor density in Mongolian gerbils and mice.

3. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation.

4. Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus.

5. Role of Helicobacter pylori cag region genes in colonization and gastritis in two animal models.

6. Characteristics of Helicobacter pylori attachment to human primary antral epithelial cells.

7. Helicobacter pylori possesses two CheY response regulators and a histidine kinase sensor, CheA, which are essential for chemotaxis and colonization of the gastric mucosa.

8. Signal transduction-mediated adherence and entry of Helicobacter pylori into cultured cells.

9. Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism.

10. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil.

1. Early Molecular Events in Murine Gastric Epithelial Cells Mediated by Helicobacter pylori CagA.