Literature DB >> 15322043

The neuroendocrine stress hormone norepinephrine augments Escherichia coli O157:H7-induced enteritis and adherence in a bovine ligated ileal loop model of infection.

Isabella Vlisidou1, Mark Lyte, Pauline M van Diemen, Pippa Hawes, Paul Monaghan, Timothy S Wallis, Mark P Stevens.   

Abstract

The role of the neuroendocrine environment in the pathogenesis of enteric bacterial infections is increasingly being recognized. Here we report that norepinephrine augments Escherichia coli O157:H7-induced intestinal inflammatory and secretory responses as well as bacterial adherence to intestinal mucosa in a bovine ligated ileal loop model of infection. Norepinephrine modulation of enteritis and adherence was dependent on the ability of E. coli O157:H7 to form attaching and effacing lesions.

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Year:  2004        PMID: 15322043      PMCID: PMC517440          DOI: 10.1128/IAI.72.9.5446-5451.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  47 in total

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  40 in total

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7.  Norepinephrine augments Salmonella enterica-induced enteritis in a manner associated with increased net replication but independent of the putative adrenergic sensor kinases QseC and QseE.

Authors:  Gillian D Pullinger; Sonya C Carnell; Fathima F Sharaff; Pauline M van Diemen; Francis Dziva; Eirwen Morgan; Mark Lyte; Primrose P E Freestone; Mark P Stevens
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9.  6-hydroxydopamine-mediated release of norepinephrine increases faecal excretion of Salmonella enterica serovar Typhimurium in pigs.

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10.  Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella.

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