| Literature DB >> 1531997 |
M McDuffie1, D Schweiger, B Reitz, A Ostrowska, A M Knight, P J Dyson.
Abstract
Analysis of TCR beta-chain V region (V beta) frequency among NOD lymphocytes reveals a profound depletion of V beta 3+ T cells, and a recent study has linked this phenomenon to the Mtv-3 insertion on chromosome 11. When the V beta 17a gene segment is introduced into mice with an nonobese diabetic mouse background, T cells bearing the TCR encoded by this gene segment are also dramatically reduced in frequency. Deletion of V beta 17a+ T cells segregates with deletion of T cells bearing V beta 3 and occurs in the absence of I-E, which had been shown in previous studies to be a major deleting element for V beta 17a+ thymocytes.Entities:
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Year: 1992 PMID： 1531997
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422