AIM: To analyse the association between potential environmental exposure to hydrocarbons and the risk of acute childhood leukaemia. METHODS: A hospital based multicentre case control study, stratified on centre, age, and sex, with 280 leukaemia cases and 285 controls was carried out. Data were collected by a standardised interview of the mothers. RESULTS: No clear association was seen between maternal occupational exposure to hydrocarbons during pregnancy and leukaemia, or between residential traffic density and leukaemia. There was an association between dwellings neighbouring a petrol station or a repair garage during childhood and the risk of childhood leukaemia (OR 4.0, 95% CI 1.5 to 10.3), with a duration trend. The association, which appeared particularly strong for acute non-lymphocytic leukaemia (OR 7.7, 95% CI 1.7 to 34.3), was not altered by adjustment for potential confounding factors. CONCLUSIONS: Results showed an association between acute childhood leukaemia and dwellings neighbouring auto repair garages and petrol stations, which are benzene emitting sources. These findings could be due to chance, although the strength of the association and the duration trend are arguments for a causal association.
AIM: To analyse the association between potential environmental exposure to hydrocarbons and the risk of acute childhood leukaemia. METHODS: A hospital based multicentre case control study, stratified on centre, age, and sex, with 280 leukaemia cases and 285 controls was carried out. Data were collected by a standardised interview of the mothers. RESULTS: No clear association was seen between maternal occupational exposure to hydrocarbons during pregnancy and leukaemia, or between residential traffic density and leukaemia. There was an association between dwellings neighbouring a petrol station or a repair garage during childhood and the risk of childhood leukaemia (OR 4.0, 95% CI 1.5 to 10.3), with a duration trend. The association, which appeared particularly strong for acute non-lymphocytic leukaemia (OR 7.7, 95% CI 1.7 to 34.3), was not altered by adjustment for potential confounding factors. CONCLUSIONS: Results showed an association between acute childhood leukaemia and dwellings neighbouring auto repair garages and petrol stations, which are benzene emitting sources. These findings could be due to chance, although the strength of the association and the duration trend are arguments for a causal association.
Authors: S Sans; P Elliott; I Kleinschmidt; G Shaddick; S Pattenden; P Walls; C Grundy; H Dolk Journal: Occup Environ Med Date: 1995-04 Impact factor: 4.402
Authors: C M van Duijn; H A van Steensel-Moll; J W Coebergh; G E van Zanen Journal: Cancer Epidemiol Biomarkers Prev Date: 1994-09 Impact factor: 4.254
Authors: Marcello Campagna; Giannina Satta; Laura Campo; Valeria Flore; Antonio Ibba; Michele Meloni; Maria Giuseppina Tocco; Giuseppe Avataneo; Costantino Flore; Silvia Fustinoni; Pierluigi Cocco Journal: Int Arch Occup Environ Health Date: 2013-12-27 Impact factor: 3.015
Authors: Julie Von Behren; Peggy Reynolds; Robert B Gunier; Rudolph P Rull; Andrew Hertz; Kevin Y Urayama; Daniel Kronish; Patricia A Buffler Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-09 Impact factor: 4.254