Literature DB >> 1531727

Huntington disease and the abuse of genetics.

P S Harper1.   

Abstract

Huntington disease, one of the longest established and most serious human genetic disorders, has been the subject of considerable abuse during the present century in relation to the application of genetic knowledge, most notably in Nazi Germany but also in other countries. This disorder provides a valuable example of how abuses in the past need to be recognized and confronted, if we are to avoid their recurrence in relation to new molecular and computing techniques in genetics.

Entities:  

Keywords:  Genetics and Reproduction

Mesh:

Year:  1992        PMID: 1531727      PMCID: PMC1684272     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN: 0002-9297            Impact factor:   11.025


  6 in total

1.  Problems in genetic prediction for Huntington's disease.

Authors:  M J Morris; A Tyler; L Lazarou; L Meredith; P S Harper
Journal:  Lancet       Date:  1989-09-09       Impact factor: 79.321

2.  Huntington disease: no evidence for locus heterogeneity.

Authors:  P M Conneally; J L Haines; R E Tanzi; N S Wexler; G K Penchaszadeh; P S Harper; S E Folstein; J J Cassiman; R H Myers; A B Young
Journal:  Genomics       Date:  1989-08       Impact factor: 5.736

3.  Adoption and genetic prediction for Huntington's disease.

Authors:  M Morris; A Tyler; P S Harper
Journal:  Lancet       Date:  1988-11-05       Impact factor: 79.321

Review 4.  Human immunodeficiency virus infection, women, and pregnancy. Ethical issues.

Authors:  K Nolan
Journal:  Obstet Gynecol Clin North Am       Date:  1990-09       Impact factor: 2.844

5.  The fate of the mentally ill in Germany during the Third Reich.

Authors:  J E Meyer
Journal:  Psychol Med       Date:  1988-08       Impact factor: 7.723

6.  Presymptomatic diagnosis of delayed-onset disease with linked DNA markers. The experience in Huntington's disease.

Authors:  J Brandt; K A Quaid; S E Folstein; P Garber; N E Maestri; M H Abbott; P R Slavney; M L Franz; L Kasch; H H Kazazian
Journal:  JAMA       Date:  1989-06-02       Impact factor: 56.272

  6 in total
  10 in total

1.  Testing for Huntington's disease.

Authors:  R Williamson
Journal:  BMJ       Date:  1992-06-20

2.  Abuse of genetics in Nazi Germany.

Authors:  P Propping
Journal:  Am J Hum Genet       Date:  1992-10       Impact factor: 11.025

3.  Geneticists' responsibility to other health care professionals and to the lay public.

Authors:  K L Garver; K LeChien
Journal:  Am J Hum Genet       Date:  1992-10       Impact factor: 11.025

4.  Genetic discrimination and insurance underwriting.

Authors:  J A Lowden
Journal:  Am J Hum Genet       Date:  1992-10       Impact factor: 11.025

5.  Eugenics and genetic discrimination.

Authors:  N A Holtzman; M A Rothstein
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

6.  Preparing for presymptomatic DNA testing for early onset Alzheimer's disease/cerebral haemorrhage and hereditary Pick disease.

Authors:  A Tibben; M Stevens; G M de Wert; M F Niermeijer; C M van Duijn; J C van Swieten
Journal:  J Med Genet       Date:  1997-01       Impact factor: 6.318

Review 7.  The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention.

Authors:  Abdelmagid M Elmatboly; Ahmed M Sherif; Dalia A Deeb; Amira Benmelouka; May N Bin-Jumah; Lotfi Aleya; Mohamed M Abdel-Daim
Journal:  Environ Sci Pollut Res Int       Date:  2020-02-19       Impact factor: 4.223

Review 8.  Huntington's Chorea-a Rare Neurodegenerative Autosomal Dominant Disease: Insight into Molecular Genetics, Prognosis and Diagnosis.

Authors:  Pratik Talukder; Annapurna Jana; Shrirupa Dhar; Saikat Ghosh
Journal:  Appl Biochem Biotechnol       Date:  2021-07-07       Impact factor: 2.926

Review 9.  Ubiquitin-proteasome system involvement in Huntington's disease.

Authors:  Zaira Ortega; Jose J Lucas
Journal:  Front Mol Neurosci       Date:  2014-09-29       Impact factor: 5.639

10.  Role of defective calcium regulation in cardiorespiratory dysfunction in Huntington's disease.

Authors:  Haikel Dridi; Xiaoping Liu; Qi Yuan; Steve Reiken; Mohamad Yehia; Leah Sittenfeld; Panagiota Apostolou; Julie Buron; Pierre Sicard; Stefan Matecki; Jérome Thireau; Clement Menuet; Alain Lacampagne; Andrew R Marks
Journal:  JCI Insight       Date:  2020-10-02
  10 in total

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