Kamel Marzouk1, Samer Saleh, Mouhamed Kannass, Om P Sharma. 1. Division of Pulmonary and Critical Care Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA. marzouk@usc.edu
Abstract
PURPOSE OF REVIEW: Interferon therapy can induce or exacerbate sarcoidosis. With the increasing use of interferons it is highly likely that more cases of sarcoidosis will be encountered by clinicians. We describe three unusual cases of interferon-induced sarcoidosis and review the most recent relevant literature on this subject. RECENT FINDINGS: Interferons, on account of their antiviral antigrowth and immunomodulatory effects, are used to treat various internal and dermatological diseases. Exogenously administered interferons stimulate the Th-1 response, which plays a major role in granuloma formation. In most of the patients with interferon-induced sarcoidosis, the disease subsides when interferon is discontinued. Occasionally, treatment with corticosteroids may become necessary. SUMMARY: Interferon therapy can induce or exacerbate sarcoidosis, the disease disappears when interferon is discontinued, sometimes treatment with corticosteroids is required.
PURPOSE OF REVIEW: Interferon therapy can induce or exacerbate sarcoidosis. With the increasing use of interferons it is highly likely that more cases of sarcoidosis will be encountered by clinicians. We describe three unusual cases of interferon-induced sarcoidosis and review the most recent relevant literature on this subject. RECENT FINDINGS: Interferons, on account of their antiviral antigrowth and immunomodulatory effects, are used to treat various internal and dermatological diseases. Exogenously administered interferons stimulate the Th-1 response, which plays a major role in granuloma formation. In most of the patients with interferon-induced sarcoidosis, the disease subsides when interferon is discontinued. Occasionally, treatment with corticosteroids may become necessary. SUMMARY: Interferon therapy can induce or exacerbate sarcoidosis, the disease disappears when interferon is discontinued, sometimes treatment with corticosteroids is required.
Authors: Stergios Tsitos; Lisa Catherina Niederauer; Paula Albert I Gracenea; Johanna Mueller; Andreas Straube; Louisa Von Baumgarten Journal: Front Neurol Date: 2022-06-20 Impact factor: 4.086
Authors: Horiana B Grosu; David E Ost; Rodolfo C Morice; George A Eapen; Liang Li; Juhee Song; Xiudong Lei; Donald R Lazarus; Roberto F Casal; Carlos A Jimenez Journal: Ann Am Thorac Soc Date: 2015-10