Literature DB >> 1531589

Activation of prothrombin in the presence of human umbilical-vein endothelial cells.

P Schoen1, C Reutelingsperger, T Lindhout.   

Abstract

Addition of Factor Xa, Factor Va and prothrombin to immobilized cultured human umbilical-vein endothelial cells resulted after a time delay in thrombin formation. The prothrombin-converting (prothrombinase) activity, however, was not associated with the cell surface. Rather, perturbation by thrombin, either formed in situ or exogenously added, induced a procoagulant phospholipid surface in the fluid phase, which, in the presence of Factor Xa and Factor Va, enabled the assembly of prothrombinase.

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Year:  1992        PMID： 1531589      PMCID： PMC1130741          DOI： 10.1042/bj2810661

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex.

Authors:  K K Hamilton; R Hattori; C T Esmon; P J Sims
Journal:  J Biol Chem       Date:  1990-03-05       Impact factor: 5.157

2.  Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

Authors:  P J Sims; E M Faioni; T Wiedmer; S J Shattil
Journal:  J Biol Chem       Date:  1988-12-05       Impact factor: 5.157

3.  Media conditioned by cultured human vascular endothelial cells inhibit the growth of vascular smooth muscle cells.

Authors:  C Willems; G C Astaldi; P G De Groot; M C Janssen; M D Gonsalvez; W P Zeijlemaker; J A Van Mourik; W G Van Aken
Journal:  Exp Cell Res       Date:  1982-05       Impact factor: 3.905

4.  Continuous flow and the prothrombinase-catalyzed activation of prothrombin.

Authors:  P Schoen; T Lindhout; G Willems; H C Hemker
Journal:  Thromb Haemost       Date:  1990-12-28       Impact factor: 5.249

5.  Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers.

Authors:  H A Andree; C P Reutelingsperger; R Hauptmann; H C Hemker; W T Hermens; G M Willems
Journal:  J Biol Chem       Date:  1990-03-25       Impact factor: 5.157

6.  Enhanced thrombin generation and platelet binding on herpes simplex virus-infected endothelium.

Authors:  M R Visser; P B Tracy; G M Vercellotti; J L Goodman; J G White; H S Jacob
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

7.  Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

Authors:  E A Jaffe; R L Nachman; C G Becker; C R Minick
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

8.  Coagulation factor Va binds to human umbilical vein endothelial cells and accelerates protein C activation.

Authors:  I Maruyama; H H Salem; P W Majerus
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

9.  Enhancement by human umbilical vein endothelial cells of factor Xa-catalyzed activation of factor VII.

Authors:  L V Rao; S I Rapaport; M Lorenzi
Journal:  Blood       Date:  1988-03       Impact factor: 22.113

Review 10.  Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance.

Authors:  R F Zwaal; E M Bevers; P Comfurius; J Rosing; R H Tilly; P F Verhallen
Journal:  Mol Cell Biochem       Date:  1989 Nov 23-Dec 19       Impact factor: 3.396
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  1 in total

1.  Phosphatidylserine-mediated adhesion of T-cells to endothelial cells.

Authors:  J Qu; L A Conroy; J H Walker; F B Wooding; J A Lucy
Journal:  Biochem J       Date:  1996-07-15       Impact factor: 3.857
  1 in total

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