| Literature DB >> 15315848 |
Taff Jones1, Sonya Cyr, Francine Allard, Nathalie Bellerose, George H Lowell, David S Burt.
Abstract
Protollin is a novel adjuvant comprising Proteosomes non-covalently complexed with LPS. Intranasal immunization of mice with Protollin combined with detergent-split influenza antigens (HA) or recombinant influenza hemagglutinin (rHA) enhanced serum IgG and mucosal IgA levels by up to 250-fold compared with immunization with the antigens alone. IFN-gamma responses were also enhanced compared to the levels produced by splenocytes from mice immunized with antigen alone, while production of IL-5 was abrogated. Mice immunized with Protollin-rHA were completely protected against lethal challenge with influenza virus, demonstrating that Protollin is an effective mucosal adjuvant for prophylactic vaccines.Entities:
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Year: 2004 PMID： 15315848 DOI： 10.1016/j.vaccine.2004.03.035
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641