Literature DB >> 15315842

DNA vaccination of pigs with open reading frame 1-7 of PRRS virus.

Annette Malene Barfoed1, Merete Blixenkrone-Møller, Merethe Holm Jensen, Anette Bøtner, Søren Kamstrup.   

Abstract

We cloned all open reading frames of a Danish isolate of porcine reproductive and respiratory syndrome (PRRS) virus in DNA vaccination vectors. Pigs were vaccinated using a gene gun with each single construct (ORF1, ORF2, ORF3, ORF4, ORF5, ORF6, or ORF7) or combinations thereof. Vaccination with ORF7 consistently induced antibodies after three vaccinations, while antibodies were only sporadically detected in the remaining groups. After six vaccinations, all pigs were inoculated with PRRS virus and the post-inoculation antibody response was studied. Pigs vaccinated with ORF1 or ORF4 were primed for antibody response against NSP2 or GP4, respectively. Neutralising antibodies were detected in all pigs, with ORF5 vaccinated pigs showing the highest titres.

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Year:  2004        PMID： 15315842     DOI： 10.1016/j.vaccine.2004.03.028

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  20 in total

1.  Evaluation of the new commercial recombinant chimeric subunit vaccine PRRSFREE in challenge with heterologous types 1 and 2 porcine reproductive and respiratory syndrome virus.

Authors:  Jiwoon Jeong; Changhoon Park; Kyuhyung Choi; Chanhee Chae
Journal:  Can J Vet Res       Date:  2017-01       Impact factor: 1.310

Review 2.  Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects.

Authors:  Wasin Charerntantanakul
Journal:  World J Virol       Date:  2012-02-12

3.  Immune responses in pigs induced by recombinant canine adenovirus 2 expressing the glycoprotein 5 of porcine reproductive and respiratory syndrome virus.

Authors:  J-X Zhou; J-D Xue; T Yu; J-B Zhang; Y Liu; N Jiang; Y-L Li; R-L Hu
Journal:  Vet Res Commun       Date:  2010-04-30       Impact factor: 2.459

4.  Effectiveness of a commercial porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine against heterologous PRRSV-1 and PRRSV-2 challenge in late-term pregnant gilts.

Authors:  Taehwan Oh; Hanjin Kim; Kee Hwan Park; Jiwoon Jeong; Ikjae Kang; Siyeon Yang; Chanhee Chae
Journal:  Can J Vet Res       Date:  2019-10       Impact factor: 1.310

5.  A transgenic Marc-145 cell line of piggyBac transposon-derived targeting shRNA interference against porcine reproductive and respiratory syndrome virus.

Authors:  Fang Zhou; Shuang Liang; An-hui Chen; Chabungbam Orville Singh; Roy Bhaskar; Yan-shan Niu; Yun-gen Miao
Journal:  Vet Res Commun       Date:  2012-06       Impact factor: 2.459

6.  Expression of the nucleocapsid protein of porcine reproductive and respiratory syndrome virus in soybean seed yields an immunogenic antigenic protein.

Authors:  Sornkanok Vimolmangkang; Ksenija Gasic; Ruth Soria-Guerra; Sergio Rosales-Mendoza; Leticia Moreno-Fierros; Schuyler S Korban
Journal:  Planta       Date:  2011-10-05       Impact factor: 4.116

7.  Epidemiology and evolutionary characteristics of the porcine reproductive and respiratory syndrome virus in China between 2006 and 2010.

Authors:  Bin Li; Liurong Fang; Xueliang Guo; Jianfeng Gao; Tao Song; Jing Bi; Kongwang He; Huanchun Chen; Shaobo Xiao
Journal:  J Clin Microbiol       Date:  2011-07-20       Impact factor: 5.948

8.  Enhanced immunogenicity of the modified GP5 of porcine reproductive and respiratory syndrome virus.

Authors:  Liurong Fang; Yunbo Jiang; Shaobo Xiao; Chuanshuang Niu; Hui Zhang; Huanchun Chen
Journal:  Virus Genes       Date:  2006-02       Impact factor: 2.332

9.  Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture.

Authors:  Jun Han; Gongping Liu; Yue Wang; Kay S Faaberg
Journal:  J Virol       Date:  2007-05-23       Impact factor: 5.103

10.  Immunogenic and protective properties of GP5 and M structural proteins of porcine reproductive and respiratory syndrome virus expressed from replicating but nondisseminating adenovectors.

Authors:  Elodie Roques; Aurélie Girard; Marie-Claude St-Louis; Bernard Massie; Carl A Gagnon; Martin Lessard; Denis Archambault
Journal:  Vet Res       Date:  2013-03-11       Impact factor: 3.683
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