| Literature DB >> 15315159 |
Huilan Zhang1, Zhenxiang Zhang, Yongjian Xu, Lihua Xing, Jianbo Liu, Jun Li, Qing Tan.
Abstract
To investigate the expression of hypoxia inducible factor 1-alpha (HIF-1alpha) and its correlation with P53 and vascular endothelial growth factor (VEGF), immunohistochemical technique was employed to detect the protein expressions of HIF-1alpha, P53 and VEGF in specimens from 57 patients with lung cancer. The results indicated that the total positive proportion of HIF-1alpha expression was 63% and the HIF-1alpha expression was more frequent in bronchiole-alveolar carcinoma (86%) than in other lung cancer. There was a strong association of HIF-1alpha with VEGF and P53 protein expressions. It is concluded that HIF-1alpha overexpression is a common event in lung cancer, which may be related to the up-regulation of the angiogenic factor VEGF and oncogene mutant P53 protein.Entities:
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Year: 2004 PMID： 15315159 DOI： 10.1007/bf02885408
Source DB: PubMed Journal: J Huazhong Univ Sci Technolog Med Sci ISSN： 1672-0733