A Helvacioglu1, R Weis. 1. University of South Alabama, School of Medicine, Mobile 36688.
Abstract
OBJECTIVE: To evaluate the immediate postoperative pain and discomfort in patients who underwent operative laparoscopy under general anesthesia with or without peritoneallidocaine and incisional bupivacaine instillations. DESIGN:Fifty-four participants were prospectively randomized to three groups: group I, intraperitoneal (IP) lidocaine + intraincisional bupivacaine; group II, intraincisional bupivacaine; and group III, no additional drugs after general anesthesia (controls). SETTING:University Hospital, Reproductive Endocrinology and Infertility Clinics. PATIENTS: Private patients needing operative laparoscopy. INTERVENTIONS: One hundred milligrams of lidocaine were instilled with the irrigation device into the peritoneal cavity at the completion of surgery. Twenty-five milligrams of bupivacaine were injected into infraumbilical and suprapubic incisions. MAIN OUTCOME MEASURES: The analgesic use and modified McGill Present Pain Intensity scores were used for pain evaluation. RESULTS: McGill Present Pain Intensity scores for pain, and narcotic use in the recovery room were less in IP lidocaine-instilled group of patients (P less than 0.05). The mean maximum plasma lidocaine level achieved was 1.01 +/- 0.25 micrograms/mL. CONCLUSIONS:Peritoneal lidocaine and incisional bupivacaine use in operative laparoscopy as described after general anesthesia is safe and effective in reducing postoperative pain in the recovery room.
RCT Entities:
OBJECTIVE: To evaluate the immediate postoperative pain and discomfort in patients who underwent operative laparoscopy under general anesthesia with or without peritoneal lidocaine and incisional bupivacaine instillations. DESIGN: Fifty-four participants were prospectively randomized to three groups: group I, intraperitoneal (IP) lidocaine + intraincisional bupivacaine; group II, intraincisional bupivacaine; and group III, no additional drugs after general anesthesia (controls). SETTING: University Hospital, Reproductive Endocrinology and Infertility Clinics. PATIENTS: Private patients needing operative laparoscopy. INTERVENTIONS: One hundred milligrams of lidocaine were instilled with the irrigation device into the peritoneal cavity at the completion of surgery. Twenty-five milligrams of bupivacaine were injected into infraumbilical and suprapubic incisions. MAIN OUTCOME MEASURES: The analgesic use and modified McGill Present Pain Intensity scores were used for pain evaluation. RESULTS: McGill Present Pain Intensity scores for pain, and narcotic use in the recovery room were less in IP lidocaine-instilled group of patients (P less than 0.05). The mean maximum plasma lidocaine level achieved was 1.01 +/- 0.25 micrograms/mL. CONCLUSIONS: Peritoneal lidocaine and incisional bupivacaine use in operative laparoscopy as described after general anesthesia is safe and effective in reducing postoperative pain in the recovery room.