Literature DB >> 15314252

NAP mechanisms of neuroprotection.

Illana Gozes1, Ruth A Steingart, Avron D Spier.   

Abstract

An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-alpha, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity. Copyright 2004 Humana Press Inc.

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Year:  2004        PMID： 15314252     DOI： 10.1385/JMN:24:1:067

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  27 in total

1.  Beta-sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma.

Authors:  J F Poduslo; G L Curran; A Kumar; B Frangione; C Soto
Journal:  J Neurobiol       Date:  1999-06-05

Review 2.  Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease.

Authors:  C Soto
Journal:  Mol Med Today       Date:  1999-08

3.  NAP accelerates the performance of normal rats in the water maze.

Authors:  Illana Gozes; Roy Alcalay; Eliezer Giladi; Albert Pinhasov; Sharon Furman; Douglas E Brenneman
Journal:  J Mol Neurosci       Date:  2002 Aug-Oct       Impact factor: 3.444

4.  A novel peptide prevents death in enriched neuronal cultures.

Authors:  I Zemlyak; S Furman; D E Brenneman; I Gozes
Journal:  Regul Pept       Date:  2000-12-22

5.  Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease.

Authors:  D Offen; Y Sherki; E Melamed; M Fridkin; D E Brenneman; I Gozes
Journal:  Brain Res       Date:  2000-01-31       Impact factor: 3.252

6.  Cloning and characterization of the human activity-dependent neuroprotective protein.

Authors:  R Zamostiano; A Pinhasov; E Gelber; R A Steingart; E Seroussi; E Giladi; M Bassan; Y Wollman; H J Eyre; J C Mulley; D E Brenneman; I Gozes
Journal:  J Biol Chem       Date:  2001-01-05       Impact factor: 5.157

7.  NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death.

Authors:  Ronen R Leker; Angella Teichner; Nikolas Grigoriadis; Haim Ovadia; Douglas E Brenneman; Mati Fridkin; Eli Giladi; Jacob Romano; Illana Gozes
Journal:  Stroke       Date:  2002-04       Impact factor: 7.914

8.  Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

Authors:  M Shoji; T E Golde; J Ghiso; T T Cheung; S Estus; L M Shaffer; X D Cai; D M McKay; R Tintner; B Frangione
Journal:  Science       Date:  1992-10-02       Impact factor: 47.728

9.  Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.

Authors:  Elena Tamagno; Maurizio Parola; Michela Guglielmotto; Gianni Santoro; Paola Bardini; Laura Marra; Massimo Tabaton; Oliviero Danni
Journal:  Free Radic Biol Med       Date:  2003-07-01       Impact factor: 7.376

10.  Injections of the neuroprotective peptide NAP to newborn mice attenuate head-injury-related dysfunction in adults.

Authors:  Roy Zaltzman; Sara M Beni; Eliezer Giladi; Albert Pinhasov; Ruth A Steingart; Jacob Romano; Esther Shohami; Illana Gozes
Journal:  Neuroreport       Date:  2003-03-03       Impact factor: 1.837
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  17 in total

Review 1.  Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress.

Authors:  Mohammed Akbar; Musthafa Mohamed Essa; Ghazi Daradkeh; Mohamed A Abdelmegeed; Youngshim Choi; Lubna Mahmood; Byoung-Joon Song
Journal:  Brain Res       Date:  2016-02-13       Impact factor: 3.252

2.  Parkinson's and Alzheimer's diseases: protein aggregations and neuroprotection.

Authors:  Illana Gozes
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444

3.  Activity-dependent neurotrophic factor-9 and NAP promote neurite outgrowth in rat hippocampal and cortical cultures.

Authors:  Virginia L Smith-Swintosky; Illana Gozes; Douglas E Brenneman; Michael R D'Andrea; Carlos R Plata-Salaman
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

4.  Nap Interferes with Hypoxia-Inducible Factors and VEGF Expression in Retina of Diabetic Rats.

Authors:  Agata Grazia D'Amico; Grazia Maugeri; Claudio Bucolo; Salvatore Saccone; Concetta Federico; Sebastiano Cavallaro; Velia D'Agata
Journal:  J Mol Neurosci       Date:  2016-12-01       Impact factor: 3.444

5.  Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death.

Authors:  Soraya Scuderi; Agata Grazia D'Amico; Alessandro Castorina; Concetta Federico; Giuseppina Marrazzo; Filippo Drago; Claudio Bucolo; Velia D'Agata
Journal:  J Mol Neurosci       Date:  2014-02-02       Impact factor: 3.444

6.  Tubulin is the target binding site for NAP-related peptides: ADNF-9, D-NAP, and D-SAL.

Authors:  Miri Holtser-Cochav; Inna Divinski; Illana Gozes
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

Review 7.  Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.

Authors:  Mansi R Khanna; Jane Kovalevich; Virginia M-Y Lee; John Q Trojanowski; Kurt R Brunden
Journal:  Alzheimers Dement       Date:  2016-10       Impact factor: 21.566

8.  Skeletal muscle tissue engineering: a maturation model promoting long-term survival of myotubes, structural development of the excitation-contraction coupling apparatus and neonatal myosin heavy chain expression.

Authors:  Mainak Das; John W Rumsey; Neelima Bhargava; Maria Stancescu; James J Hickman
Journal:  Biomaterials       Date:  2009-07-22       Impact factor: 12.479

9.  The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush.

Authors:  T Jehle; C Dimitriu; S Auer; R Knoth; M Vidal-Sanz; I Gozes; W A Lagrèze
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-04-15       Impact factor: 3.117

10.  NAP reduces murine microvascular endothelial cells proliferation induced by hyperglycemia.

Authors:  Agata Grazia D'Amico; Soraya Scuderi; Grazia Maugeri; Sebastiano Cavallaro; Filippo Drago; Velia D'Agata
Journal:  J Mol Neurosci       Date:  2014-05-30       Impact factor: 3.444
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