Literature DB >> 15313458

Signal transducer and activator of transcription 5 (STAT5).

Miranda Buitenhuis1, Paul J Coffer, Leo Koenderman.   

Abstract

Signal transducer and activator of transcription 5 (STAT5) activity is induced by a plethora of cytokines and growth factors resulting in transcriptional activation of specific target genes. STAT5 plays an important role in a variety of cellular processes, including proliferation, differentiation, and apoptosis. Aberrant regulation of STAT5 has been observed in solid tumors as well as in patients with either chronic or acute myeloid leukemia. Kinase inhibitors are currently being developed to negatively regulate STAT5 activity for clinical purposes.

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Year:  2004        PMID： 15313458     DOI： 10.1016/j.biocel.2003.11.008

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  25 in total

1.  Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics.

Authors:  Jason D Hoffert; Trairak Pisitkun; Fahad Saeed; Jae H Song; Chung-Lin Chou; Mark A Knepper
Journal:  Mol Cell Proteomics       Date:  2011-11-21       Impact factor: 5.911

2.  Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma.

Authors:  Yinling Mao; Zhiwei Li; Changjie Lou; Yanqiao Zhang
Journal:  Int J Colorectal Dis       Date:  2010-11-16       Impact factor: 2.571

3.  Transforming growth factor-beta downregulates interleukin-2-induced phosphorylation of signal transducer and activator of transcription 5 in human renal cell carcinoma.

Authors:  Cheryn Song; Sun-Young Jun; Jun-Hyuk Hong; Hanjong Ahn
Journal:  J Cancer Res Clin Oncol       Date:  2007-02-06       Impact factor: 4.553

4.  Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.

Authors:  Blanca E Ruiz-Medina; Jeremy A Ross; Robert A Kirken
Journal:  J Biol Chem       Date:  2015-07-07       Impact factor: 5.157

5.  Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.

Authors:  Rémy Nyga; Christian Pecquet; Noria Harir; Haihua Gu; Isabelle Dhennin-Duthille; Aline Régnier; Valérie Gouilleux-Gruart; Kaïss Lassoued; Fabrice Gouilleux
Journal:  Biochem J       Date:  2005-08-15       Impact factor: 3.857

6.  Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation.

Authors:  Yong Deuk Kim; Tiangang Li; Seung-Won Ahn; Don-Kyu Kim; Ji-Min Lee; Seung-Lark Hwang; Yong-Hoon Kim; Chul-Ho Lee; In-Kyu Lee; John Y L Chiang; Hueng-Sik Choi
Journal:  J Biol Chem       Date:  2012-09-12       Impact factor: 5.157

7.  Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.

Authors:  Jesse Rowley; Archana Monie; Chien-Fu Hung; T-C Wu
Journal:  J Immunol       Date:  2008-12-15       Impact factor: 5.422

8.  Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.

Authors:  Monika Kasprzycka; Qian Zhang; Agnieszka Witkiewicz; Michal Marzec; Magdalena Potoczek; Xiaobin Liu; Hong Yi Wang; Michael Milone; Samik Basu; Joanne Mauger; John K Choi; J Todd Abrams; J Steven Hou; Alain H Rook; Eric Vonderheid; Anders Woetmann; Niels Odum; Mariusz A Wasik
Journal:  J Immunol       Date:  2008-08-15       Impact factor: 5.422

9.  Reaction-diffusion modeling ERK- and STAT-interaction dynamics.

Authors:  Nikola Georgiev; Valko Petrov; Georgi Georgiev
Journal:  EURASIP J Bioinform Syst Biol       Date:  2006

10.  Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland.

Authors:  Sarah J Santos; Sandra Z Haslam; Susan E Conrad
Journal:  Endocrinology       Date:  2007-09-20       Impact factor: 4.736
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