| Literature DB >> 1531345 |
A Jawien1, D F Bowen-Pope, V Lindner, S M Schwartz, A W Clowes.
Abstract
Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.Entities:
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Year: 1992 PMID： 1531345 PMCID： PMC442880 DOI： 10.1172/JCI115613
Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808