| Literature DB >> 15313399 |
A Ivana Scovassi1, Marc Diederich.
Abstract
Poly(ADP-ribosylation) is a post-translational modification of proteins playing a crucial role in DNA repair, replication, transcription and cell death. In this paper, the main features of this process have been reviewed, focusing on the best known poly(ADP-ribose) polymerizing enzyme, PARP-1, a DNA nick-sensor protein that uses beta-NAD+ to form polymers of ADP-ribose. The modulation of poly(ADP-ribosylation) during apoptosis and the possible effects of its inhibition on cell metabolism are discussed.Entities:
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Year: 2004 PMID: 15313399 DOI: 10.1016/j.bcp.2004.04.023
Source DB: PubMed Journal: Biochem Pharmacol ISSN: 0006-2952 Impact factor: 5.858