Literature DB >> 15313246

Engineering of non-natural receptors.

Pascale Mathonet1, Jacques Fastrez.   

Abstract

Rational design, usually guided by computational prediction, and selection from libraries of variants of natural proteins have been used with success in the engineering of novel non-natural receptors. Many of these engineered protein binders will find use in biotechnological, diagnostic and medical applications, sometimes in the place of natural antibodies.

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Year:  2004        PMID: 15313246     DOI: 10.1016/j.sbi.2004.06.007

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN: 0959-440X            Impact factor:   6.809


  7 in total

1.  Molecular imaging and therapy -- a programme based on the development of new biomolecules.

Authors:  Uwe Haberkorn; Michael Eisenhut
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-12       Impact factor: 9.236

2.  Engineering a signal transduction mechanism for protein-based biosensors.

Authors:  Jonathan E Kohn; Kevin W Plaxco
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-26       Impact factor: 11.205

3.  Active TEM-1 beta-lactamase mutants with random peptides inserted in three contiguous surface loops.

Authors:  Pascale Mathonet; Julie Deherve; Patrice Soumillion; Jacques Fastrez
Journal:  Protein Sci       Date:  2006-09-08       Impact factor: 6.725

4.  Selection of allosteric beta-lactamase mutants featuring an activity regulation by transition metal ions.

Authors:  Pascale Mathonet; Humberto Barrios; Patrice Soumillion; Jacques Fastrez
Journal:  Protein Sci       Date:  2006-09-08       Impact factor: 6.725

Review 5.  The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins.

Authors:  Shohei Koide; Sachdev S Sidhu
Journal:  ACS Chem Biol       Date:  2009-05-15       Impact factor: 5.100

6.  Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.

Authors:  François Stricher; Chih-chin Huang; Anne Descours; Sophie Duquesnoy; Olivier Combes; Julie M Decker; Young Do Kwon; Paolo Lusso; George M Shaw; Claudio Vita; Peter D Kwong; Loïc Martin
Journal:  J Mol Biol       Date:  2008-07-01       Impact factor: 5.469

7.  Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides.

Authors:  Kenneth J Oh; Kevin J Cash; Kevin W Plaxco
Journal:  Chemistry       Date:  2009       Impact factor: 5.236

  7 in total

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