Literature DB >> 15312688

Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival.

Ross D Farhadieh1, Robert Smee, Kim Ow, Jia Lin Yang, Pamela J Russell, Roger Crouch, Paul Jackson, Ian V Jacobson.   

Abstract

Oral Squamous Cell Carcinoma (OSCC) is a common malignancy. Treatment failure is mainly due to loco-regional disease recurrence. KAI1 is a newly discovered metastasis suppressor gene. Fifty-seven patients with primary OSCC underwent surgery alone or surgery and adjuvant radiotherapy. Immunohistochemical evaluation of KAI1/CD82 and p53 proteins was carried out on specimen obtained at surgery. Within neoplastic fields, KAI1/CD82 expression was downregulated and negative in 42/57 (73.7%) cases. p53 expression was positive in 26/57 (45.6%) cases. No correlation was noted between KAI1/CD82 and p53 expression or clinicopathological parameters. Univariate and multivariate Cox proportional hazard models showed a correlation between KAI1/CD82 expression with disease free survival (P = 0.01, P = 0.009) and overall survival (P = 0.04, P = 0.053) respectively.

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Year:  2004        PMID： 15312688     DOI： 10.1016/j.canlet.2004.03.004

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  13 in total

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7.  Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma.

Authors:  C Protzel; C Kakies; B Kleist; M Poetsch; J Giebel
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8.  Elevated KAI1 Protein Expression Identified in Malignant Melanoma.

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9.  Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia.

Authors:  P Nankivell; H Williams; C McConkey; K Webster; A High; K MacLennan; B Senguven; P Rabbitts; H Mehanna
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10.  KAI-1 and p53 expression in oral squamous cell carcinomas: Markers of significance in future diagnostics and possibly therapeutics.

Authors:  Namrata N Patil; Vijay Wadhwan; Minal Chaudhary; Abhishek Singh Nayyar
Journal:  J Oral Maxillofac Pathol       Date:  2016 Sep-Dec
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