Literature DB >> 15311678

Mitochondrial alterations in muscle biopsies of patients on statin therapy.

S Gambelli1, M T Dotti, A Malandrini, M Mondelli, M L Stromillo, C Gaudiano, A Federico.   

Abstract

Clinical and biopsy study of nine patients on statin therapy suffering from various myopathic syndromes is reported. Biopsy findings showed non specific myopathic signs and mitochondrial changes, such as subsarcolemmal accumulation, morphological alterations, lipid increase and Cox-negative fibers. These findings confirm that statins may cause muscle damage and impair oxidative metabolism.

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Year:  2004        PMID： 15311678

Source DB:  PubMed          Journal:  J Submicrosc Cytol Pathol        ISSN： 1122-9497


  10 in total

1.  Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA's Adverse Event Reporting System.

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Journal:  Drug Saf       Date:  2018-04       Impact factor: 5.606

2.  β-Adrenergic receptor blockade blunts postexercise skeletal muscle mitochondrial protein synthesis rates in humans.

Authors:  Matthew M Robinson; Christopher Bell; Frederick F Peelor; Benjamin F Miller
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-05-25       Impact factor: 3.619

Review 3.  Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions.

Authors:  QiPing Feng; Russell A Wilke; Tesfaye M Baye
Journal:  Pharmacogenomics       Date:  2012-04       Impact factor: 2.533

4.  Amyotrophic lateral sclerosis-like conditions in possible association with cholesterol-lowering drugs: an analysis of patient reports to the University of California, San Diego (UCSD) Statin Effects Study.

Authors:  Beatrice A Golomb; Edwin K Kwon; Sabrina Koperski; Marcella A Evans
Journal:  Drug Saf       Date:  2009       Impact factor: 5.606

Review 5.  Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.

Authors:  Beatrice A Golomb; Marcella A Evans
Journal:  Am J Cardiovasc Drugs       Date:  2008       Impact factor: 3.571

6.  Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content.

Authors:  Craig A Goodman; Derk Pol; Evelyn Zacharewicz; Robert S Lee-Young; Rod J Snow; Aaron P Russell; Glenn K McConell
Journal:  PLoS One       Date:  2015-05-28       Impact factor: 3.240

7.  Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney.

Authors:  Giovanni Corsetti; Giuseppe D'Antona; Chiara Ruocco; Alessandra Stacchiotti; Claudia Romano; Laura Tedesco; Francesco Dioguardi; Rita Rezzani; Enzo Nisoli
Journal:  Amino Acids       Date:  2014-06-13       Impact factor: 3.520

8.  Fat-free mass and fasting glucose values in patients with and without statin therapy assigned to age groups between <60 and >75 years.

Authors:  Alexander Dzien; Hannes Winner; Engelbert Theurl; Christine Dzien-Bischinger; Monika Lechleitner
Journal:  Obes Facts       Date:  2013-02-21       Impact factor: 3.942

Review 9.  Sporadic Inclusion Body Myositis: An Acquired Mitochondrial Disease with Extras.

Authors:  Boel De Paepe
Journal:  Biomolecules       Date:  2019-01-07

10.  Trimetazidine restores the positive adaptation to exercise training by mitigating statin-induced skeletal muscle injury.

Authors:  Ming Song; Fang-Fang Chen; Yi-Hui Li; Lei Zhang; Feng Wang; Ran-Ran Qin; Zhi-Hao Wang; Ming Zhong; Meng-Xiong Tang; Wei Zhang; Lu Han
Journal:  J Cachexia Sarcopenia Muscle       Date:  2017-11-19       Impact factor: 12.910
  10 in total

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