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Literature DB >> 15310216

Phototoxicity against tumor cells and Sindbis virus by an octahedral rhodium bisbipyridyl complex and evidence for the genome as a target in viral photoinactivation.

Elton L Menon¹, Rushika Perera, Maribel Navarro, Richard J Kuhn, Harry Morrison.

Abstract

An octahedral rhodium complex (cis-dichloro(dipyrido[3,2a-2',3'c]phenazine)(1,10-phenanthroline)rhodium(III) chloride; DPPZPHEN) has been prepared that can penetrate tumor cell membranes and the Sindbis viral capsid. The compound is phototoxic to these entities when irradiated with UVA light. Model studies with calf thymus and supercoiled plasmid DNA indicate that the complex can both bind with, and nick, nucleic acid. Analysis of Sindbis virus, following irradiation with the metal complex, confirmed that the viral genome was rendered noninfectious by this treatment.

Entities: Chemical Disease Species

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Year: 2004 PMID： 15310216 DOI： 10.1021/ic0498586

Source DB: PubMed Journal: Inorg Chem ISSN： 0020-1669 Impact factor: 5.165

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Cited

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3. Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences.

Authors: Ana Zamora; Erin Wachter; María Vera; David K Heidary; Venancio Rodríguez; Enrique Ortega; Vanesa Fernández-Espín; Christoph Janiak; Edith C Glazer; Giampaolo Barone; José Ruiz
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3 in total

Phototoxicity against tumor cells and Sindbis virus by an octahedral rhodium bisbipyridyl complex and evidence for the genome as a target in viral photoinactivation.

1. The elements of life and medicines.

2. Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro.

3. Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences.

2. Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PL^pro.