| Literature DB >> 15309690 |
Andrew E Timms1, Alison M Crane, Anne-Marie Sims, Heather J Cordell, Linda A Bradbury, Aaron Abbott, Mark R E Coyne, Owen Beynon, Ibi Herzberg, Gordon W Duff, Andrei Calin, Lon R Cardon, B Paul Wordsworth, Matthew A Brown.
Abstract
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS.Entities:
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Year: 2004 PMID： 15309690 PMCID： PMC1182046 DOI： 10.1086/424695
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025