Literature DB >> 15309517

CIN-ful cancers.

Harith Rajagopalan1, Christoph Lengauer.   

Abstract

Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.

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Year:  2004        PMID： 15309517     DOI： 10.1007/s00280-004-0889-8

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  10 in total

1.  Replication-compromised cells require the mitotic checkpoint to prevent tetraploidization.

Authors:  Zilai Zhang; Sumit Arora; Yanjiao Zhou; Athena Cherry; Teresa S-F Wang
Journal:  Chromosoma       Date:  2010-09-09       Impact factor: 4.316

2.  Chromosomal instability and human cancer.

Authors:  Franziska Michor
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-03-29       Impact factor: 6.237

3.  Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function.

Authors:  Huaxin Si; Erle S Robertson
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

4.  Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells.

Authors:  William T Silkworth; Isaac K Nardi; Lindsey M Scholl; Daniela Cimini
Journal:  PLoS One       Date:  2009-08-10       Impact factor: 3.240

5.  General aspects of colorectal cancer.

Authors:  Josep J Centelles
Journal:  ISRN Oncol       Date:  2012-11-14

6.  EB1 is required for spindle symmetry in mammalian mitosis.

Authors:  Anke Brüning-Richardson; Kelly J Langford; Peter Ruane; Tracy Lee; Jon M Askham; Ewan E Morrison
Journal:  PLoS One       Date:  2011-12-21       Impact factor: 3.240

Review 7.  DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons.

Authors:  Therese Wilhelm; Maha Said; Valeria Naim
Journal:  Genes (Basel)       Date:  2020-06-10       Impact factor: 4.096

8.  Transient defects of mitotic spindle geometry and chromosome segregation errors.

Authors:  William T Silkworth; Daniela Cimini
Journal:  Cell Div       Date:  2012-08-11       Impact factor: 5.130

9.  Genetic Heterogeneity and Clonal Evolution of Tumor Cells and their Impact on Precision Cancer Medicine.

Authors:  Hatem E Sabaawy
Journal:  J Leuk (Los Angel)       Date:  2013-11-18

Review 10.  Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor‑promoting factors (Review).

Authors:  Zhengyi Wang; Xiaoying Wu
Journal:  Oncol Rep       Date:  2021-07-19       Impact factor: 3.906
  10 in total

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