Literature DB >> 15309411

Heat shock protein 27 protects the heart against myocardial infarction.

Christopher A Efthymiou1, Mihaela M Mocanu, Jackie de Belleroche, Dominic J Wells, David S Latchmann, Derek M Yellon.   

Abstract

Heat shock proteins (hsp) represent a group of chaperones which protects the cells against a diversity of stresses. It has been demonstrated that hsp27 is constitutively present in cells where it plays an important role in different cytoprotective processes which ultimately inhibit cell death. We investigated the response of the isolated perfused mouse heart over expressing hsp27 to the ischaemia/reperfusion injury using infarct size as an end point. Our results show for the first time that mice over expressing hsp27 (verified by Western blotting analysis) were found to be protected from lethal ischaemia/reperfusion injury compared to their negative littermates.

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Year:  2004        PMID： 15309411     DOI： 10.1007/s00395-004-0483-6

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  40 in total

Review 1.  Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease.

Authors:  Monte S Willis; Cam Patterson
Journal:  Circulation       Date:  2010-10-26       Impact factor: 29.690

2.  Protein O-GlcNAcylation: A critical regulator of the cellular response to stress.

Authors:  John C Chatham; Richard B Marchase
Journal:  Curr Signal Transduct Ther       Date:  2010-01

3.  Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation.

Authors:  Norbert Fülöp; Zhenghao Zhang; Richard B Marchase; John C Chatham
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-01-05       Impact factor: 4.733

4.  Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.

Authors:  John S Giuliano; Patrick M Lahni; Hector R Wong; Derek S Wheeler
Journal:  Open Inflamm J       Date:  2011-10-07

5.  Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia.

Authors:  Louise van der Weerd; Mohammed Tariq Akbar; Romina Aron Badin; Lauren M Valentim; David L Thomas; Dominic J Wells; David S Latchman; David G Gadian; Mark F Lythgoe; Jackie S de Belleroche
Journal:  J Cereb Blood Flow Metab       Date:  2009-12-09       Impact factor: 6.200

6.  Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NFκB-mediated leucocyte recruitment after myocardial infarction.

Authors:  Yana Wang; Jiali Liu; Qiuyue Kong; Hao Cheng; Fei Tu; Peng Yu; Ying Liu; Xiaojin Zhang; Chuanfu Li; Yuehua Li; Xinxu Min; Shuya Du; Zhengnian Ding; Li Liu
Journal:  Cardiovasc Res       Date:  2019-01-01       Impact factor: 10.787

Review 7.  The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses.

Authors:  John C Chatham; Richard B Marchase
Journal:  Biochim Biophys Acta       Date:  2009-07-14

8.  Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients.

Authors:  Terence Murphy; Pauline M Walsh; Peter P Doran; Kevin J Mulhall
Journal:  J Transl Med       Date:  2010-05-10       Impact factor: 5.531

9.  Sulindac confers high level ischemic protection to the heart through late preconditioning mechanisms.

Authors:  Ian Moench; Howard Prentice; Zach Rickaway; Herbert Weissbach
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-02       Impact factor: 11.205

10.  Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes.

Authors:  Tiane Dai; Mina Patel-Chamberlin; Rama Natarajan; Ivan Todorov; Jun Ma; Janine LaPage; Lynetta Phillips; Cynthia C Nast; Diana Becerra; Peter Chuang; Lili Tong; Jacqueline de Belleroche; Dominic J Wells; Ying Wang; Sharon G Adler
Journal:  Endocrinology       Date:  2009-03-26       Impact factor: 4.736
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