Literature DB >> 15308190

Improvement of dose calculation accuracy for BNCT dosimetry by the multi-voxel method in JCDS.

H Kumada1, K Yamamoto, T Yamamoto, K Nakai, Y Nakagawa, T Kageji, A Matsumura.   

Abstract

To carry out boron neutron capture therapy (BNCT) clinical trials based on accurate dosimetry of several dose components given to a patient, we had developed the JAERI computational dosimetry system (JCDS), which can determine the absorbed doses by numerical simulation. The verification results of initial version of JCDS indicated that JCDS causes characteristic discrepancy, when JCDS estimates a sharp change arising such as near the surface. The aim of this study is to improve the accuracy of the BNCT dosimetry efficiently. The multi-voxel calculation method that reconstructs the original voxel model by combining several voxel cell sizes such as 0.125, 1 and 8 cm(3) has been developed. To verify the accuracy of the method, the calculation results were compared with the phantom experimental data. Furthermore, to verify its practicality to BNCT, retrospective evaluation of an actual BNCT in JRR-4 was performed by the multi-voxel method. The results of the comparison with the phantom experiments demonstrated that the calculation accuracy for the distributions of the thermal neutron flux was improved by employing the multi-voxel method. The computing time using the multi-voxel method increased only approximately 33% compared to the conventional uniform 1cm(3) voxel method. These results proved that the multi-voxel calculation enables JCDS to more accurately estimate the absorbed doses to a patient by efficient calculations.

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Year:  2004        PMID: 15308190     DOI: 10.1016/j.apradiso.2004.05.067

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  2 in total

1.  Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck.

Authors:  Teruhito Aihara; Norimasa Morita; Nobuhiko Kamitani; Hiroaki Kumada; Koji Ono; Junichi Hiratsuka; Tamotu Harada
Journal:  Int J Clin Oncol       Date:  2013-06-25       Impact factor: 3.402

Review 2.  A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond.

Authors:  Yoshitaka Matsumoto; Nobuyoshi Fukumitsu; Hitoshi Ishikawa; Kei Nakai; Hideyuki Sakurai
Journal:  J Pers Med       Date:  2021-08-23
  2 in total

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