| Literature DB >> 15308096 |
Jonathan W Yewdell1, Margarita Del Val.
Abstract
Highlights from a Fundación Juan March Interdisciplinary Meeting. CD8+ T cells (TCD8+) play a critical role in immunity to viruses. A central feature of antiviral TCD8+ responses is immunodominance: out of thousands of potential target peptides, only a handful generate measurable responses. A recent Fundación Juan March Meeting brought together scientists working on the various steps in antigen presentation and T cell biology that contribute to immunodominance, whose understanding is key to rationally developing vaccines meant to elicit effective antiviral TCD8+ responses.Entities:
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Year: 2004 PMID： 15308096 DOI： 10.1016/j.immuni.2004.06.015
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745