| Literature DB >> 15306133 |
Yukio Kawahara1, Kyoko Ito, Hui Sun, Masayuki Ito, Ichiro Kanazawa, Shin Kwak.
Abstract
We report the cloning of human GluR4c, an alternative splicing isoform of GluR4. Similar to rodent and chick GluR4c mRNA, human GluR4c had a 113-bp insert containing a stop codon, resulting in a short C terminus. The expression of human GluR4c was widespread in the brain, and was upregulated with development in the cerebellum and cerebral cortex where the level of it was about 30% of total GluR4 mRNA in adult stage. The GluR4 subunit may play a pivotal role in regulating channel properties as well as trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in the adult human brain.Entities:
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Year: 2004 PMID： 15306133 DOI： 10.1016/j.molbrainres.2004.05.020
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X