Literature DB >> 15306132

Opposed regulation of aluminum-induced apoptosis by glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in rat brains.

Seung-Ju Yang1, Jong Eun Lee, Kwan Ho Lee, Jae-Wan Huh, Soo Young Choi, Sung-Woo Cho.   

Abstract

When intracisternally injected to rat brain, aluminum induced apoptosis as assessed by DNA fragmentation and activation of caspase-3 and caspase-12. Co-administration of glial cell line-derived neurotrophic factor (GDNF) effectively prevented aluminum-induced cell death through reduced apoptosis whereas brain-derived neurotrophic factor (BDNF) accelerated aluminum-induced apoptosis, suggesting that the extent of aluminum neurotoxicity in vivo may depend on the biological activity of the neurotrophic factors.

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Year:  2004        PMID： 15306132     DOI： 10.1016/j.molbrainres.2004.05.016

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  3 in total

Review 1.  Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

Authors:  Daniel Krewski; Robert A Yokel; Evert Nieboer; David Borchelt; Joshua Cohen; Jean Harry; Sam Kacew; Joan Lindsay; Amal M Mahfouz; Virginie Rondeau
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2007       Impact factor: 6.393

2.  Zinc, a neuroprotective agent against aluminum-induced oxidative DNA injury.

Authors:  Neha Singla; D K Dhawan
Journal:  Mol Neurobiol       Date:  2013-02-19       Impact factor: 5.590

3.  Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer's Disease via Antioxidant Genes, APP Gene, and miRNA-101.

Authors:  Elnaz Amanzadeh Jajin; Abolghasem Esmaeili; Soheila Rahgozar; Maryam Noorbakhshnia
Journal:  Front Neurosci       Date:  2021-02-25       Impact factor: 4.677
  3 in total

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