AIM: The aim of this study was to examine the relationship between indoor exposures and the home environment, and the development of recurrent wheezing during infancy. METHODS: A birth cohort, comprising 4089 children, was followed. Information on exposures was obtained shortly after birth, and episodes of wheezing were recorded when the infants were 1 and 2 y of age. In a nested case-control study, 181 infants were enrolled, who had three or more reported episodes of wheezing after 3 mo of age combined with either use of inhaled steroids or symptoms of bronchial hyper-reactivity, and 359 age-matched controls. Home inspections were performed during the winter following enrolment, and indoor conditions were measured. RESULTS: Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated. The OR for recurrent infant wheezing associated with signs of dampness reported prospectively by parents was 1.4 (0.9-2.2), and the OR for observed signs of dampness at home inspections was 1.6 (1.0-2.5). A trend was found in the risk of recurrent wheezing in relation to the number of indicators of dampness: OR 1.3 (0.8-2.2) for one sign of dampness and OR 2.7 (1.3-5.4) for three or more signs of dampness. Newly painted surfaces in the child's bedroom was associated with an increased OR for recurrent wheezing: 1.7 (1.3-2.6). CONCLUSION: Indicators of dampness, as well as recently repainted interior surfaces, appear to be associated with recurrent infant wheezing, with a strengthened effect of combined indoor exposures.
AIM: The aim of this study was to examine the relationship between indoor exposures and the home environment, and the development of recurrent wheezing during infancy. METHODS: A birth cohort, comprising 4089 children, was followed. Information on exposures was obtained shortly after birth, and episodes of wheezing were recorded when the infants were 1 and 2 y of age. In a nested case-control study, 181 infants were enrolled, who had three or more reported episodes of wheezing after 3 mo of age combined with either use of inhaled steroids or symptoms of bronchial hyper-reactivity, and 359 age-matched controls. Home inspections were performed during the winter following enrolment, and indoor conditions were measured. RESULTS: Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated. The OR for recurrent infantwheezing associated with signs of dampness reported prospectively by parents was 1.4 (0.9-2.2), and the OR for observed signs of dampness at home inspections was 1.6 (1.0-2.5). A trend was found in the risk of recurrent wheezing in relation to the number of indicators of dampness: OR 1.3 (0.8-2.2) for one sign of dampness and OR 2.7 (1.3-5.4) for three or more signs of dampness. Newly painted surfaces in the child's bedroom was associated with an increased OR for recurrent wheezing: 1.7 (1.3-2.6). CONCLUSION: Indicators of dampness, as well as recently repainted interior surfaces, appear to be associated with recurrent infantwheezing, with a strengthened effect of combined indoor exposures.
Authors: Jennie Cox; Patrick Ryan; Jeff Burkle; Roman Jandarov; Mark J Mendell; Gurjit Khurana Hershey; Grace LeMasters; Tiina Reponen Journal: Environ Epidemiol Date: 2020-06-19
Authors: B Behbod; J E Sordillo; E B Hoffman; S Datta; T E Webb; D L Kwan; J A Kamel; M L Muilenberg; J A Scott; G L Chew; T A E Platts-Mills; J Schwartz; B Coull; H Burge; D R Gold Journal: Clin Exp Allergy Date: 2015-01 Impact factor: 5.018
Authors: Reginald Quansah; Maritta S Jaakkola; Timo T Hugg; Sirpa A M Heikkinen; Jouni J K Jaakkola Journal: PLoS One Date: 2012-11-07 Impact factor: 3.240
Authors: Rosa M Pacheco-Gonzalez; Javier Mallol; Dirceu Solé; Paul L P Brand; Virginia Perez-Fernandez; Manuel Sanchez-Solis; Luis Garcia-Marcos Journal: NPJ Prim Care Respir Med Date: 2016-01-21 Impact factor: 2.871