| Literature DB >> 15302957 |
Hironari Niiya1, Taichi Azuma1, Lei Jin1, Naoyuki Uchida1, Atsushi Inoue1, Hitoshi Hasegawa1, Shigeru Fujita1, Mikiko Tohyama1, Koji Hashimoto1, Masaki Yasukawa1.
Abstract
DC-SIGN expressed on dendritic cells (DCs) efficiently binds and transmits various pathogens, including human immunodeficiency virus, to lymphoid tissues and permissive cells. Consequently, alteration of DC-SIGN expression may affect susceptibility and resistance to pathogens. The present study shows that infection with human herpesvirus 6 (HHV-6) induces downregulation of DC-SIGN expression on immature DCs. Expression levels of DC-SIGN mRNA and intracellular protein appeared to decrease following infection with HHV-6, indicating that downregulation of surface DC-SIGN occurs at the transcriptional level. Downregulation of DC-SIGN was not induced by inoculation of UV-inactivated HHV-6 or culture supernatant of HHV-6-infected DCs, indicating that replication of HHV-6 in DCs is required for downregulation of DC-SIGN. The present study demonstrates for the first time that expression of DC-SIGN is altered at the transcriptional level by virus infection.Entities:
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Year: 2004 PMID： 15302957 DOI： 10.1099/vir.0.80095-0
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891