| Literature DB >> 15302942 |
Almut Scherer1, John Frater, Annette Oxenius, Juliet Agudelo, David A Price, Huldrych F Günthard, Martin Barnardo, Luc Perrin, Bernard Hirschel, Rodney E Phillips, Angela R McLean.
Abstract
There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. Immunological data provide an explanatory mechanism for this relationship. Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV.Entities:
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Year: 2004 PMID： 15302942 PMCID： PMC514467 DOI： 10.1073/pnas.0404091101
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205