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Literature DB >> 15302925

The essence of total synthesis.

Abstract

For the past century, the total synthesis of natural products has served as the flagship of chemical synthesis and the principal driving force for discovering new chemical reactivity, evaluating physical organic theories, testing the power of existing synthetic methods, and enabling biology and medicine. This perspective article seeks to examine this time-honored and highly demanding art, distilling its essence in an effort to ascertain its power and future potential.

Mesh：

Substances：
Biological Products

Year: 2004 PMID： 15302925 PMCID： PMC514411 DOI： 10.1073/pnas.0403799101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. The development of L2X2Ru=CHR olefin metathesis catalysts: an organometallic success story.

Authors: T M Trnka; R H Grubbs
Journal: Acc Chem Res Date: 2001-01 Impact factor: 22.384

2. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 3. Completion and synthesis of advanced analogues.

Authors: K C Nicolaou; Y-L Zhong; P S Baran; J Jung; H-S Choi; W H Yoon
Journal: J Am Chem Soc Date: 2002-03-13 Impact factor: 15.419

3. The second total synthesis of diazonamide A.

Authors: K C Nicolaou; Paraselli Bheema Rao; Junliang Hao; Mali Venkat Reddy; Gerasimos Rassias; Xianhai Huang; David Y-K Chen; Scott A Snyder
Journal: Angew Chem Int Ed Engl Date: 2003-04-17 Impact factor: 15.336

4. Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis.

Authors: K C Nicolaou; Tamsyn Montagnon; Scott A Snyder
Journal: Chem Commun (Camb) Date: 2003-03-07 Impact factor: 6.222

5. Total Synthesis of Nominal Diazonamides-Part 2: On the True Structure and Origin of Natural Isolates Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Welch Foundation, and the Advanced Research Program of the Texas Higher Education Coordinating Board. We are grateful to Professor Michael Roth for his time, insight, and advice.

Authors: Jing Li; Anthony W. G. Burgett; Lothar Esser; Carlos Amezcua; Patrick G. Harran
Journal: Angew Chem Int Ed Engl Date: 2001-12-17 Impact factor: 15.336

Review 6. The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis.

Authors: K C Nicolaou; Phil S Baran
Journal: Angew Chem Int Ed Engl Date: 2002-08-02 Impact factor: 15.336

Review 7. Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions.

Authors: Dale L Boger; Joel Desharnais; Kevin Capps
Journal: Angew Chem Int Ed Engl Date: 2003-09-15 Impact factor: 15.336

8. A variation of the sulfide contraction procedure for synthesis of corrinoid systems.

Authors: E Götschi; W Hunkeler; H J Wild; P Schneider; W Fuhrer; J Gleason; A Eschenmoser
Journal: Angew Chem Int Ed Engl Date: 1973 Impact factor: 15.336

9. Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.

Authors:
Journal: Angew Chem Int Ed Engl Date: 1999-08 Impact factor: 15.336

10. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 1. Racemic and asymmetric synthesis of bicyclo[4.3.1] key building blocks.

Authors: K C Nicolaou; J Jung; W H Yoon; K C Fong; H-S Choi; Y He; Y-L Zhong; P S Baran
Journal: J Am Chem Soc Date: 2002-03-13 Impact factor: 15.419

12 in total

Review 1. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors: K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal: Chem Soc Rev Date: 2012-06-28 Impact factor: 54.564

Review 2. Is there no end to the total syntheses of strychnine? Lessons learned in strategy and tactics in total synthesis.

Authors: Jeffrey S Cannon; Larry E Overman
Journal: Angew Chem Int Ed Engl Date: 2012-03-19 Impact factor: 15.336

Review 3. Chemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics.

Authors: Sayaka Masuko; Robert J Linhardt
Journal: Future Med Chem Date: 2012-03 Impact factor: 3.808

4. Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst.

Authors: Bin Tan; Nuno R Candeias; Carlos F Barbas
Journal: Nat Chem Date: 2011-05-08 Impact factor: 24.427

5. A Reactivity-Driven Approach to the Discovery and Development of Gold-Catalyzed Organic Reactions.

Authors: Nathan D Shapiro; F Dean Toste
Journal: Synlett Date: 2010-03-01 Impact factor: 2.454

6. Visible-light-mediated conversion of alcohols to halides.

Authors: Chunhui Dai; Jagan M R Narayanam; Corey R J Stephenson
Journal: Nat Chem Date: 2011-01-09 Impact factor: 24.427

7. Chemoselectivity: the mother of invention in total synthesis.

Authors: Ryan A Shenvi; Daniel P O'Malley; Phil S Baran
Journal: Acc Chem Res Date: 2009-04-21 Impact factor: 22.384

8. A unified strategy for enantioselective total synthesis of cladiellin and briarellin diterpenes: total synthesis of briarellins E and F and the putative structure of alcyonin and revision of its structure assignment.

Authors: Olivier Corminboeuf; Larry E Overman; Lewis D Pennington
Journal: J Org Chem Date: 2009-08-07 Impact factor: 4.354

Review 9. Syntheses of Complex Terpenes from Simple Polyprenyl Precursors.

Authors: Claire S Harmange Magnani; Danny Q Thach; Karl T Haelsig; Thomas J Maimone
Journal: Acc Chem Res Date: 2020-03-23 Impact factor: 22.384

Review 10. Towards the optimal screening collection: a synthesis strategy.

Authors: Thomas E Nielsen; Stuart L Schreiber
Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336