M A Belfort1, K J Moise. 1. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030.
Abstract
OBJECTIVES: The purpose of this study was to determine the effect of a 6 gm intravenous bolus of magnesium sulfate on maternal brain blood flow velocity waveforms in patients with preeclampsia. STUDY DESIGN:Twelve patients with preeclampsia were randomized to two groups and studied with Doppler ultrasonography before and immediately after infusion of either a 6 gm intravenous loading dose of magnesium sulfate or a placebo. The middle cerebral, common carotid, and internal carotid arteries were studied. RESULTS:Magnesium sulfate significantly reduced the pulsatility index in the middle cerebral artery (change in pulsatility index = -0.16 + 0.09) when compared with the placebo (change in pulsatility index = -0.02 + 0.06), p = 0.01. There were no significant changes in the Doppler indexes of the carotid vessels. CONCLUSIONS: These data suggest that magnesium sulfate vasodilates the smaller-diameter intracranial vessels distal to the middle cerebral artery and may exert its main effect in the prophylaxis and treatment of eclampsia by relieving cerebral ischemia.
RCT Entities:
OBJECTIVES: The purpose of this study was to determine the effect of a 6 gm intravenous bolus of magnesium sulfate on maternal brain blood flow velocity waveforms in patients with preeclampsia. STUDY DESIGN: Twelve patients with preeclampsia were randomized to two groups and studied with Doppler ultrasonography before and immediately after infusion of either a 6 gm intravenous loading dose of magnesium sulfate or a placebo. The middle cerebral, common carotid, and internal carotid arteries were studied. RESULTS:Magnesium sulfate significantly reduced the pulsatility index in the middle cerebral artery (change in pulsatility index = -0.16 + 0.09) when compared with the placebo (change in pulsatility index = -0.02 + 0.06), p = 0.01. There were no significant changes in the Doppler indexes of the carotid vessels. CONCLUSIONS: These data suggest that magnesium sulfate vasodilates the smaller-diameter intracranial vessels distal to the middle cerebral artery and may exert its main effect in the prophylaxis and treatment of eclampsia by relieving cerebral ischemia.
Authors: J Andrew McKee; Randall P Brewer; Gary E Macy; Cecil O Borel; James D Reynolds; David S Warner Journal: Neurocrit Care Date: 2005 Impact factor: 3.210
Authors: Frederic P Collignon; Jonathan A Friedman; David G Piepgras; Mark A Pichelmann; Jon I McIver; L Gerard Toussaint; Robyn L McClelland Journal: Neurocrit Care Date: 2004 Impact factor: 3.210